231例药品不良反应报告回顾性分析

Retrospective Analysis on Reports of 231 Cases of Adverse Drug Reaction

目的探讨我院药物不良反应发生的相关因素及特点,为临床合理用药提供依据。方法收集本院2008-06～2010-05上报的231例ADR资料,针对ADR所涉及的患者情况、用药情况以及不良反应临床表现、转归、因果关系评价等内容进行回顾性分析。结果 231例ADR报告涉及73种药品,以抗感染药物所致的ADR居多,占51.51%;其次为循环系统用药,占11.69%;其他占36.80%。ADR累及最多的器官为皮肤及其附件;静脉注射是引起ADR的主要给药途径;性别对ADR发生率的影响无明显差异。结论应加强对医护人员的专业培训,合理使用抗生素,不断提高临床用药水平,规范注射剂的使用,可大幅减少ADR的发生。

Objective To investigate the related factors and characteristics of adverse drug reactions （ADR） in People＇s Hospital of Qingyuan, so as to provide basis for the clinical application of drugs. Methods A total of 231 cases of reported ADR data in our hospital from June 2008 - May 2010 were collected, and retrospective analyzed on the following aspects： drug application, adverse clinical manifestations, outcome, causality assessment, and so on. Results A total of 73 drugs were involved in all the 231 cases of ADR. ADR caused by anti-infective drugs accounted for 51.51%, ranked first; followed by circulatoly system drugs, accounting for 11.69%, and other drugs account for 36. 80%. Skin and its appendages were most common affected by ADR, and intravenous injection was the main cause of ADR. Gender differences in the incidence of ADR had no significant differences. Conclusion We should strengthen the professional training of medical staff, encourage rational application of antibiotics, continuously improve the level of clinical cardiovascular drug application, and standardize the use of injections. These steps would significantly reduce the incidence of ADR.