和胃消痞合剂对大鼠慢性胃炎pH值和胃黏膜病理影响

Effect of Hewei Xiaopi Mixture on Gastric Mucosa Pathological Histology and Gastric Juice pH Value in Rats Model of Chronic Gastritis

目的观察和胃消痞合剂对慢性胃炎大鼠胃液pH值和胃黏膜病理的影响。方法采用综合法对大鼠进行造模,造模后给予和胃消痞合剂进行治疗。观察病理学改变,并测定胃液的pH值。结果给予和胃消痞合剂治疗后,大鼠胃黏膜炎症分级明显降低,胃液pH值明显升高。结论和胃消痞合剂能明显升高胃液pH值,并且改善慢性胃炎大鼠胃黏膜炎症,保护和修复损伤胃黏膜作用。

Objective To observe the effect Hewei Xiaopi mixture（HXM）on gastric juice pH value of gastritis rats and pathological histology of their gastric mucosa.Methods The chronic gastritis（CG） rat model was made by synthetically method.After model was the made scucsessfully,the rats were treated by HXM for 1 month,then their gastric mucosa pathological histology and gastric juice pH value were observed.Results The gastric mucosa pathological histology ratios of HXM treated rats were significantly lower（P0.01） and their gastric juice pH value were significantly higher（P0.01）.Conclusion HXM could treat rats with CG,it can ameliorate gastric mucosa and raise the gastric juice pH value.