异种脱细胞真皮基质联合Bio-oss Collagen修复牙槽骨缺损的临床研究

Clinical application of acellular dermal matrix combined with Bio-oss Collagen to repair alveolar bone defects

目的:通过引导骨再生(GBR)技术评估异种脱细胞真皮基质(acellular dermal matrix,ADM)与Bio-ossCollagen联合应用在修复牙槽骨缺损中的作用。方法:选择拔牙术后牙槽骨缺损严重的病例18例,拔牙同期在拔牙创植入Bio-oss Collagen并覆盖异种脱细胞真皮基质(海奥生物膜),术后2周拆线,3个月复诊并拍摄X线片。结果:术后经临床检查和X线检查,18例患者植骨区新骨形成良好,牙槽骨高度与丰满度明显改善,术区骨生成良好。结论:临床上异种脱细胞真皮基质与Bio-oss Collagen联合应用能有效修复牙槽骨缺损,改善修复前的骨条件。

Objective：To investigate the effect of guided bone regeneration of acellular dermal matrix（ADM） combined with Bio-oss Collagen in alveolar defect.Method：18 cases patients with severe alveolar bone resorption or damage were included.Bone defect after teeth extraction were very serious and the residual height and width of the alveolar bone were very limited in all these cases.Bio-oss Collagen was delivered into the sockets immediately after tooth extraction and covered with acellular dermal matrix membrane.Suture was removed 2 weeks postop,and the alveolar bone was regularly examined at the 3rd month.Result：New bone was found to form well in both physical examination and X-ray examination in all the 18 cases in the 3rd month.The height and width of the alveolar bone were significantly increased,providing a good bone condition for later FPD prosthetic treatment.Conclusion：Acellular dermal matrix combined with Bio-oss Collagen can improve the bone condition before restoration in clinical.