肺炎球菌表面黏附素A和表面膜蛋白A的研究进展

Progress in Research on Pneumococcal Surface Adhesin A and Surface Membrane Protein A

肺炎球菌表面黏附素A(Pneumococcal surface adhesin A,PsaA)为脂蛋白,属于ABC型转运蛋白复合物(ATPbinding cassette transporter),存在于各型肺炎球菌中,是其重要的毒力因子和黏附因子,编码基因高度保守,具有转运Mn2+及黏附功能。肺炎球菌表面膜蛋白A(Pneumococcal surface protein A,PspA)是与其毒力相关的一种重要的表面抗原,在目前发现的所有临床分离的肺炎球菌中几乎均存在,其编码基因变异性较大。PsaA和PspA均为肺炎球菌的保护性抗原和新型肺炎球菌疫苗的研发热点之一。本文就这两种蛋白的结构、功能、免疫学特性及应用的研究进展作一综述。

Pneumococcal surface adhesin A （PsaA） is a lipoprotein and a ATP binding cassette transporter. As an important virulence factor and adhesion factor, it exists in all known serotypes of Streptococcus pneumoniae, of which the encoding genes are highly conserved, has multiple functions such as Mn2＋ transport and adherence. However, as an important surface antigen associated with virulence, Pneumococcal surface protein A （PspA） existed in almost all the clinical isolates of S. pneumoniae, of which the encoding genes are highly variable. Both PsaA and PspA are the protective antigens of S. pneumoniae and the hot spots of developing novel S. pneumoniae vaccines. This paper reviews the progress in research on structure, function, immunological characteristics and possihle annlicaticm nf PsaA and PsnA.