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乙型肝炎病毒共价闭合环状DNA及其检测的研究进展

Advance in Research on Covalently Closed Circular DNA of Hepatitis B Virus
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摘要 共价闭合环状DNA(Covalently closed circular DNA,cccDNA)是乙型肝炎病毒(Hepatitis B Virus,HBV)复制的模板,也是慢性乙肝患者持续感染的主要原因。由于核苷类药物对cccDNA无抑制作用,因此不能从根本上清除病毒,也就不能彻底治疗乙肝。本文对HBV cccDNA的最新研究进展及检测作一综述。 Covalently closed circular DNA （cccDNA） is a template for replication of hepatitis B （HB） virus and a main cause for persistent infection in patients with chronic HB. Nucleosides as drugs can not remove the virus completely so as to treat HB effectively, since they have no inhibitory effect on cccDNA. This paper reviews the latest advance in research and detection of cccDNA of HBV.
作者 苏怀彬 胡接力 黄爱龙
机构地区 重庆医科大学感染性疾病分子生物学教育部重点实验室
出处 《中国生物制品学杂志》 CAS CSCD 2011年第11期1373-1376,共4页 Chinese Journal of Biologicals
基金 国家自然科学基金项目资助(81000732)
关键词 肝炎病毒 乙型 共价闭合环状DNA Hepatitis virus, B Covalently closed circular DNA （cccDNA）
分类号 R373.21 [医药卫生—病原生物学]
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参考文献11

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中国生物制品学杂志
2011年 第11期

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