摘要
目的:探讨血尿酸(SUA)水平与2型糖尿病(T2DM)患者血管并发症的关系及可能的作用机制。方法:收集1040例T2DM患者,根据患者血尿酸水平分为高尿酸血症(HUA,男性≥420μmol/L,女性绝经后≥420μmol/L,绝经前≥360μmol/L)组117例和正常血尿酸(NUA)组923例,比较2组间主要临床指标以及血管并发症发生情况的差异。结果:(1)HUA组糖尿病肾病(DN)、高血压、脑血管病变发病率均高于NUA组,差异有统计学意义(P<0.01)。(2)HUA与NUA组间体质量指数(BMI)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)的差异有统计学意义(均P<0.01)。(3)多因素非条件Logistic回归分析示BMI、TG、HDL-C、HbA1c为血尿酸水平的影响因素。结论:T2DM合并高尿酸血症患者血管并发症的发生率更高,应重视血尿酸这一危险因素。
Objective:To investigate the relationship between serum uric acid (SUA) and vascular complications in patients with type 2 diabetes mellitus (T2DM),and the possible mechanism thereof.Methods:The collected clinical data of 1 040 patients with T2DM were retrospectively reviewed.According to SUA levels,1 040 patients of T2DM were divided into hyperuricemia (HUA) group (n=117) and normal uric acid (NUA) group (n=923).The differences in clinical indicators and the incidence of vascular complications were compared between patients of two groups.Results:(1) The incidence rates of diabetic nephropathy (DN),hypertension and cerebrovascular complications were significantly higher in patients of HUA group than those of NUA group (P 0.01).(2) There were significant differences in body mass index (BMI),triglyceride (TG),high density lipoprotein cholesterol (HDL-C) and hemoglobin A1C (HbA1c) between HUA group and NUA group (P 0.01).(3)The multivariable non-conditional logistic analysis showed that the values of BMI,TG,HDL-C and HbA1c were influencing factors of SUA.Conclusion:The incidence rate of vascular complications was higher in T2DM patients with hyperuricemia.Therefore,much attention should be paid to the risk factors for SUA.
出处
《天津医药》
CAS
北大核心
2011年第11期1006-1008,共3页
Tianjin Medical Journal