摘要
目的:观察丹参酮ⅡA与阿托伐他汀钙联合治疗对合并大血管病变2型糖尿病患者血浆脂质过氧化产物和IL-6水平的影响。方法:将合并大血管病变的66例2型糖尿病患者随机分为两组,其中,实验组34例,给予丹参酮ⅡA与阿托伐他汀钙联合治疗;对照组32例,给予阿托伐他汀钙治疗,总疗程2周。比较治疗前后两组患者氧化低密度脂蛋白(ox-LDL)和白介素-6(IL-6)水平的变化。结果:治疗前,两组患者ox-LDL、MDA和IL-6水平均无显著性差异(P>0.05);治疗后,两组患者ox-LDL、MDA和IL-6水平较治疗前显著降低(均为P<0.05);治疗后,实验组ox-LDL、MDA和IL-6水平的减少较对照组更具显著性(P<0.05)。结论:丹参酮ⅡA与阿托伐他汀钙联合治疗能有效抑制2型糖尿病患者IL-6的表达,减轻脂质过氧化损伤。
Objective： To investigate the effect of tanshinoneⅡA combined with atorvastatin calcium on lipid peroxidation and IL-6 levels in patients with type 2 diabetes with macroangiopathy.Methods： A total of 68 type 2 diabetes patients with macrovascular lesions were divided into tanshinoneⅡA ＋ atorvastatin group（combined treatment group,n=34） and atorvastatin group（control group,n=32）.The total treatment time was two weeks.Plasma levels of ox-LDL,MDA and IL-6 in the two groups were compared before and after treatment.Results： There were no significant differences about ox-LDL,MDA and IL-6 levels between the two groups before treatment（all P0.05）.After two weeks＇ treatment,the levels of ox-LDL,MDA,and IL-6 were decreased significantly in both groups（all P0.05）.The decrease of those indexes were more significantly in combined group in compared to control group（all P0.05）.Conclusion： TanshinoneⅡA combined with atorvastatin calcium has significant effect on suppressing the expression of IL-6 and reducing lipid peroxidation injury in patients with type 2 diabetes and macroangiopathy.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2011年第6期800-802,812,共4页
Medical Journal of Wuhan University
