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曼月乐降低三苯氧胺引起的子宫内膜病变的研究 被引量：4

Research on alleviation of tamoxifen-induced endometrial lesions by Mirena
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摘要 三苯氧胺是雌激素受体阳性的乳腺癌患者内分泌治疗的首选药物。其抗雌激素作用用于乳腺癌治疗,但类雌激素样的作用可能导致子宫内膜病变,长期使用可增加子宫内膜癌的发病率。本文旨在探讨三苯氧胺引起子宫内膜病变的作用机制以及左炔诺孕酮宫内缓释系统(曼月乐)对三苯氧胺引起的相关子宫内膜病变的治疗及预防作用。 Tamoxifen is widely used as hormonal therapy for premenopausal women with estrogen receptor-positive breast cancer.It has exhibited anti-estrogenic activity for breast cancer,but has estrogenic effects on endometrium,which may increase the incidence of endometrial carcinoma.This article reviews the mechanism of tamoxifen,its effect on the endometrium,as well as the treatment and prevention of endometrium lesions with Mirena,an agent of intrauterine levonorgestrel-releasing system.
作者 傅韵 庄志刚
机构地区 同济大学附属第一妇婴保健院乳腺外科
出处 《同济大学学报（医学版）》 CAS 2011年第5期114-118,共5页 Journal of Tongji University(Medical Science)
基金 上海市自然科学基金(09zr1424800) 上海市申康前沿课题(SHDC12010116)
关键词 三苯氧胺 乳腺肿瘤 子宫内膜病变 左炔诺孕酮宫内缓释系统 tamoxifen breast cancer endometriual lesions levonorgestrel-releasing intrauterine system
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献25

  • 1Vogelvang TE,van der Mooren MJ,Mijatovic V, et al. Emerging selective estrogen receptor modulators: special focus on effects on coronary heart disease in postmeno-pausal women[J]. Drugs, 2006,66(2) : 191 -221.
  • 2Santen RJ. Effect of endocrine therapies on bone in breast cancer patients[ J]. Clin Endocrinol Metab, 2011, 96(2) : 308 -319.
  • 3Cole LK, Jacobs RL, Vance DE. Tamoxifen induces tfiacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis[ J ]. Hepatology, 2010,52(4) : 1258 - 1265.
  • 4Otsuka I, Takahashi S, O'uchi K. Clinicopathological features of endometrial carcinoma in tamoxifen- and toremifene-treated breast cancer patients [ J ]. Gan To Kagaku Ryoho, 2010,37(2) : 279 -283.
  • 5Neven P, Van Den Broecke R. Tamoxifen or aromatase inhibitors in breast cancer: efficacy and safety. [J] Acta Chir Belg, 2007,107(3) : 240-256.
  • 6Wood CE, Kaplan JR, Fontenot MB, et al. Endo- metrial profile of tamoxifen and low-dose estradiol combination therapy [ J ]. Clin Cancer Res, 2010,16 (3) : 946 - 956.
  • 7Hachisuga T, Tsujioka H, Fukuoka M, et al. Monitoring of endometrial K-ras mutation in tamoxifen- treated patients with breast cancer [ J ]. Int J Gynecol Cancer. 2009.19(6), 1052 - 1056.
  • 8Altaner S, Gueer F, Tokatli F. Expression of bcl-2 and ki-67 in tamoxifen-associated endometrial polyps: com- parison with postmenopausal polyps [ J ]. Onkologie, 2006,29(8 -9) : 376-380.
  • 9Shang Y. Molecular mechanisms of oestrogen and SERMs in endometrialcarcinogesis [ J ]. Nat Rev Cancer, 2006,6(5) ;360-368.
  • 10Perlman S, Vaisbuch E, Ben-Atie. A Tamoxifen treatment and malignant endometrial tumors-what's new?[J]. Harefuah,2006,145(3): 219-222.

二级参考文献37

  • 1邓姗,郎景和.左炔诺孕酮宫内缓释系统的临床功用及相关基础研究[J].国外医学（妇产科学分册）,2004,31(5):285-288. 被引量：148
  • 2李书娴,高淑华.绝经后阴道出血患者诊断性刮宫前B超检测子宫内膜的价值[J].中华妇产科杂志,1997,32(1):31-33. 被引量：136
  • 3徐青,陈艳,岳红,叶宁荷.人工流产术后与经期放置左炔诺孕酮宫内缓释系统临床效果比较[J].中国妇幼保健,2007,22(21):2968-2970. 被引量：6
  • 4Megan NB, Paul DB. The levonorgestrel-releasing intrauterine system: safety, efficacy, and patient acceptability[J]. Ther Clin Risk Manag,2009,5:561 -574.
  • 5吴明辉.临床技术操作规范.计划生育学分册[M].北京:人民军医出版社,2003.
  • 6Roy SN, Bhattacharya S. Benefits and risks of pharmacological agents used for the treatment of menorrhagia [ J ]. Drug Saf,2004,27 (2) :75 - 90.
  • 7Xiao BL, Wu SC, Chong J, et al. Therapeutic effects of the levonorgestrel-releasing intrauterine system in the treatment of idiopathic menorrhagia [ J ]. Fertil Steril, 2003,79(4) :963 -969.
  • 8[1]Love RR,Mazess RB,Barden HS,et al.Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer.N Engl J Eed,1992,326:852-856.
  • 9[2]Love RR,Wieve DA,Newcomb PA,et al.Effects of tamoxifen on cardiovascular risk factors in postmenopausal women.Ann Intern Med,1991,115:860-864.
  • 10[3]Cohen I.Endometrial pathologies associated with postmenopausal tamoxifen treatment.Gynecol Oncol,2004,94:256-266.

共引文献69

同被引文献34

  • 1邓姗,郎景和.左炔诺孕酮宫内缓释系统的临床功用及相关基础研究[J].国外医学（妇产科学分册）,2004,31(5):285-288. 被引量：148
  • 2高雨农,蒋国庆.释放左旋18甲基炔诺酮宫内节育器对三苯氧胺引起子宫内膜病变的治疗[J].中国妇产科临床杂志,2004,5(5):359-362. 被引量：10
  • 3戴黎华,万玉萍,蒋冰,等.曼月乐对乳腺癌患者子宫内膜的影响[J].中国保健营养:中旬刊,2012,23(11):18.
  • 4Chan SS,Tam WH,Yeo W,et al.A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women[J].BJOG,2007,114(12):1510-1515.
  • 5Neven P,Van Den Broecke R.Tamoxifen or aromatase inhibitors in breast cancer:efficacy and safety[J].Acta Chir Belg,2007,107(3):240-256.
  • 6Vosse M,Renard F,Coibion M,et al.Endometrial disorders in 406 breast cancer patients on tamoxifen:the case for less intensive monitoring[J].Eur J Obstet Gynecol Reprod Biol,2002,101(1):58-63.
  • 7Schmidt D.Changes in the endometrium after tamoxifen therapy[J].Pathologe,2006,27(1):27-32.
  • 8Mattson L.Cost effectiveness in obstetrics and gynecology:The levonorgestrel intrauterine system[J].Minn Med,2012,95(3):51-54.
  • 9Kesim MD,Aydin Y,Atis A,et al.Long-term effects of the levonorgestrel-releasing intrauterine system on serum lipids and the endometrium in breast cancer patients taking tamoxifen[J].Climacteric,2008,11(3):252-257.
  • 10Gardner FJ,Konje JC,Bell SC,et al.Preventionof tamoxifen induced endometrial polyps using a levonorgestrel releasing intrauterine system long-term follow-up of a randomised control trial[J].Gynecol Oncol,2009,114(3):452-456.

引证文献4

二级引证文献16

同济大学学报（医学版）
2011年 第5期

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