紧密连接蛋白occludin与肿瘤相关性的研究进展

Relationship between tight-junction-protein occludin and tumor

目的:总结occludin与肿瘤发生、发展和转移的研究进展。方法:应用Medline、PubMed及CNKI期刊全文数据库检索系统,以"occludin、信号传导、细胞转移和肿瘤"等为关键词,检索1998-01-2010-07的相关文献。纳入标准:1)occlu-din的一般特性;2)occludin与肿瘤分级、增殖和分化的关系;3)occludin与癌基因和抑癌基因;4)occludin与细胞信号传导;5)occludin与肿瘤的侵袭和转移。根据纳入标准,符合分析的文献38篇。结果:occludin是新近发现的一类黏附分子,能够介导上皮细胞及内皮细胞中紧密连接的形成。occludin的表达降低能够促进肿瘤的发生、发展及转移。结论:恶性肿瘤通过降低occludin的表达,使肿瘤细胞增殖、转移和侵袭能力大大加强,促进肿瘤的发展。occludin有可能为人类肿瘤的诊断和治疗方法提供新的科学依据,但是具体机制和方法尚待进一步研究。

OBJECTIVE： To review the documents about the re- lationship between occludin and tumor＇s occurrence, development and transfer. METHODS： PubMed, Medline and CNKI periodical full- text databases were retrieved with the key words of occludin, signal transduction,cell metastasis and tumor. The pertinent literatures f tom 01-1998 to 07-2010 was screened. The inclusion criteria ：1）The general characteristics of occludin; 2）the relationship between occludin and tumor cell proliferation and differentiation; 3） the relation-ship between occludin and oncogene,tumor suppressor genes; 4） the relationship between occludin and cell signal transduetion; 5） the relationship between occludin and tumor invasion,metastasis. Eventually,38 documents were internalized. RESULTS： occludin is a newly discovered classes of adhesion molecules, which can mediate the formation of tight junction in epithelial cell and endothelial cell. The lower expression of occludin can promote tumorigenesis and development. CONCLUSIONS： Malignant tumors by reducing the expression of occludin, are greatly enhanced malignant cell proliferation, metastasis, invasion and promoted the development of malignant tumors. Oecludin can be provided new scientific evidence for human cancer diagnosis and treatment, but the specific mechanisms and methods should be further studied.