摘要
目的:通过数值计算,判断Y型动脉血管中,血流动力学特性对分叉处粥样斑块病变产生和发展的影响。方法:利用边界元方法[4,5],计算了Y型动脉血管,主管病变前后的血液流场、血管壁切应力、压力等血液流体动力学特性,通过对计算结果的分析和比较对粥样病变产生和发展的原因做出了分析。边界元方法由于只在边界离散时作了近似,因而计算精度较高,对于象分叉血管这类复杂边界问题,有较强的适应性。结果:计算结果显示,分叉处管壁切应力明显大于主管壁切应力,说明了分叉处易产生粥样斑块的流体动力学原因;而病变的产生使血管腔变窄,病变斑块顶部血流速度、切应力变大,上、下游血流速度、切应力变小,说明了粥样斑块变厚和附壁延伸的流体动力学原因[7];另外,病变前后血管壁压力的计算结果显示,病变的产生对动脉血压有一定的影响。结论:通过对Y型分叉血管血液流体动力学特性的计算,进一步说明,边界元方法对分叉血管,以及分叉处有病变血管,这类复杂边界问题的计算,方便、快捷、精度高、节约机时,可为生物流体力学的深入研究提供一种可靠、有效的方法[8,9]。
Objective: It's judged that the effect of hemodynamic characteristics for the cause and development of theatherosclerotic lesion in Y bifurcation arterial by numerical.Methods: A kind of Y bifurcation arterial's hemodynamic characteristics such as blood flowing velocity vector,the shear stress and pressure at the vessel wall are calculated,studied and compared with the boundary element method.The method has higher precision because it is only approximate on the border, and it has a strong adaptability for complex border issue.Results: The hemodynamic reasons of lesions producing and developing are reasonably explained.It is shown that the blood hydrokinetic characteristics play a great important role in the cause and development of theatherosclerotic lesion.Conclusions: The boundary element method is unique to solve the complex border issue,such as bifurcation arterial flow.It is a reliable and availability method for biological hydrodynamic deep study.
出处
《中国医学物理学杂志》
CSCD
2011年第5期2937-2940,共4页
Chinese Journal of Medical Physics
基金
国家自然科学基金资助项目(No.11005058
No.10825208)
关键词
分叉血管
粥样病变
切应力
压力
边界元方法
bifurcation vessel
theatherosclerotic lesion
shear stress
pressure
boundary element method