USMM技术在丹参提取分离中的应用探讨

USMM technology application in extraction and separation of Salvia miltiorrhiza

目的:探讨USMM联用技术在丹参活性成分提取分离中的应用。方法:采用SFE-CO2提取分离丹参酮类脂溶性成分,超声提取丹参酚酸类水溶性成分,膜分离与大孔树脂纯化丹参水提物,以丹参活性成分的转移率及纯度为考察指标,探索USMM技术在丹参提取分离中的可行性。结果:丹参SFE-CO2萃取工艺稳定、可行;丹参SFE渣超声提取物丹参酚酸类成分提取率高;大孔树脂纯化技术能提高丹参活性成分的纯度;膜分离及膜分离与大孔树脂技术联用对丹参酚酸的纯化工艺还有待进一步研究。结论:USMM技术应用于丹参活性成分提取分离基本可行。

Objective： To investigate USMM coupled techniques applied in active ingredient extraction and separation of Salvia.Method： Supercritical fluid extraction（SFE） CO2 was used to extract and separate tanshinone liposoluble constituent,ultrasonic was used to extract danshen phenolic acids ternate,membrane separation and macroporous resin was used to purify water extraction from HDP.Transfer rate and purity of Danshen active ingredients were employed as the investigation indexes,the feasibility of USMM technology used in extraction and separation S.miltiorrhiza was investigated.Result： SFE-CO2 extraction process for S.miltiorrhiza was stable and feasible.Danshen phenolic acids extracted from slag of SFE-CO2 by ultrasound got a high yield.Macroporous resin purification technology could improve the purity of active ingredients of S.miltiorrhiza.Membrane separation and membrane separation coupled with macroporous resin technology applied to the purification process of S.miltiorrhiza phenolic acids still needed further research.Conclusion： It is feasible basically that USMM technology apply in extraction and separation of Salvia active ingredient.