甘草次酸抗肿瘤作用机制的研究进展

Research progress of anticancer mechanism of glycyrrhetinic acid

甘草次酸是中药甘草的主要有效成分之一。近年来,甘草次酸的抗肿瘤活性受到了广泛关注。研究表明,甘草次酸可以通过诱导肿瘤细胞凋亡、阻遏细胞周期、抑制肿瘤细胞侵袭、诱导肿瘤细胞分化、抑制肿瘤多药耐药等途径发挥抗癌作用,并能与化疗药物协同作用,对于促癌剂诱发的癌变也表现出一定的抑制功能。随着甘草次酸抗肿瘤作用机制的进一步阐明,其在肿瘤临床治疗中将具有广阔的开发应用前景。

Glycyrrhetinic acid is a major active ingredient in licorice,a famous traditional Chinese medicine.Many studies on its anti-tumor activities and low toxicity to normal cells have attracted a great deal of attention.Reports indicated that glycyrrhetinic acid inhibited the growth of tumor cells through inducing apoptosis,differentiation and the block of cell cycle,suppressing tumor metastasis,reversing the multidrug resistance.Glycyrrhetinic acid also presented synergistic effects combined with chemotherapeutics and could inhibit the carcinogenesis induced by carcinogen.With further studies on mechanism of anticancer actions,glycyrrhetinic acid is being expected to have a good prospect of development and application for cancer therapy.