摘要
目的 探讨胃癌组织中ASPP1蛋白表达规律及其与p53表达状态的相关性及与临床病理特征的关系.方法 采用免疫组织化学PV-6000法检测30例胃癌和15例相应癌旁组织ASPP1蛋白和p53的表达,比较ASPP1在胃癌组织与癌旁组织中表达的差异,并分析其与p53表达及临床病理特征的相关性.结果 胃癌组织中ASPP1的表达显著低于癌旁正常胃组织（P〈0.01）,ASPP1与患者的性别、年龄和浸润深度、分化程度、临床分期及淋巴结转移无关（P〉0.05）.而ASPP1的表达在p53阴性状态下,胃癌组织中ASPP1的表达显著高于癌旁正常胃组织（P〈0.05）;在p53阳性状态下,胃癌组织中ASPP1的表达与癌旁正常胃组织无明显差异（P〉0.05）.结论 在p53阴性的状态下,人类胃癌组织中ASPP1低表达,ASPP1的表达降低可能与胃癌的发生密切相关.
Objective To study the expression of ASPP1 protein in gastric carcinoma and to explore its relationship with p53, prognosis and pathological characters of gastric carcinoma. Methods The immunohistochemical method was used to detect the expression of p53 and ASPPI in 30 cases of gastriC： carcinoma and 15 cases adjacent gastric carcinoma. The differences nf ASPPI expression in gastric carcinoma anct adjacent gastric carcinoma,as well as its relationship with p53 expression and clinical characteristics were analyzed. Results Ttle positive expression rate of ASPPI in gastric carcinoma was significantly lower than that of actjacent gastric carcinoma（ P 〈 0.01 ）. ASPP1 protein expression in gastric carcinoma patients was similar to patients in different genders, ages, pathology types, pathology grades and clinical stages. ASPPI protein expression in p53-negative gastric carcinoma was significantly different from that in the adjacent tissues （ P 〈 0.05 ）. ASPPI protein expression in p53-positive gastric carcinoma was similar to those of the adjacent cancer tissues（ P 〉 0.05 ）. Conclusion The low expression level of ASPP1 in gastric＇ carcinoma suggested that ASPPI may play an import role in genesis of gastric carcinoma.
出处
《潍坊医学院学报》
2011年第3期167-169,共3页
Acta Academiae Medicinae Weifang
