期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

糖尿病性心肌病发病机制的实验研究进展 被引量：6

下载PDF
导出
摘要 研究显示，各种心血管并发症如大中动脉和冠状动脉粥样硬化增加均与糖尿病（DM）有关，而微血管病变（除视网膜和肾脏病变外）也可引起心脏结构和功能病理性改变。1972年Rubler等将这种DM患者在无冠心病和高血压情况下发生的心室功能紊乱定义为DM性心肌病。现将近年来DM性心肌病发病机制的实验研究进展综述如下。
作者 武琦 吕祥威 姚艳敏 徐彤彤
机构地区 桂林医学院附属医院
出处 《山东医药》 CAS 北大核心 2011年第43期114-115,共2页 Shandong Medical Journal
关键词 心肌病 糖尿病性 发病机制 实验研究
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献11

  • 1Hamby RI, Zoneraich S, Sherman L, et al. Diabetic cardiomyopa- thy[J]. JAMA, 1974,229(13) :1749-1754.
  • 2Greer J J, Ware DP, Lefer DJ. Myocardial infarction and heart fail- ure inthe db/db diabetic mouse[J]. Am J Physiol Heart Circ Physi- ol, 2006,290( 1 ) :146-153.
  • 3Aasum E, Hafstad AD, Severson DL, et al. Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice [ J ]. Diabetes, 2003,52 ( 2 ) :434-441.
  • 4Cesario DA, Brar R, Shivkumar K. Alterations in ion channel phys- iology in diabetic cardiomyopathy[ J]. Endocrinol Metab Clin North Am, 2006,35(3) :601- 610.
  • 5Trost SU, Belke DD, Bluhm WF, et al. Overexpression of the sar- coplasmic reticulum Ca^2+ -ATPase improves myocardial contractility in diabetic cardiomyopathy [ J]. Diabetes, 2002,51 (4) : 1166 - 1171.
  • 6曹建雷,熊世熙,宋陈芳,曹新营.卡托普利与贝那普利对糖尿病大鼠心肌间质重构的影响[J].山东医药,2008,48(42):13-15. 被引量：2
  • 7Liu X, Suzuki H, Sethi R, et al. Blockade of the renin-angiotensin system attenuates sarcolemma and sarcoplasmic reticulum remodeling in chronic diabetes[J]. Ann N Y Acad Sci, 2006,1084(4) :141- 154.
  • 8Yaras N, Bilginoglu A, Vassort G, et al. Restoration of diabetesin- dueed abnormal local Ca2 + release in cardiomyocytes by angiotensin Ⅱ receptor blockade[J]. Am J Physiol Heart Cite Physiol, 2007, 292(2) :912-920.
  • 9Shen X, Zheng S, Metreveli NS, et al. Protection of cardiacmito- ehondria by overexpression of MnSOD reduces diabetic eardiomyopa- thy[J]. Diabetes, 2006,55(3) :798-805.
  • 10Coort SL, Hasselbaink DM, Koonen DP, et al. Enhanced sar- colemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats [ J ]. Diabetes, 2004,53 ( 7 ) : 1655- 1663.

二级参考文献5

共引文献1

同被引文献58

  • 1张兆国.准确解读心电图ST-T改变的临床价值——ST-T改变不等于心肌缺血[J].心电图杂志（电子版）,2013,2(3):187-189. 被引量：3
  • 2Koh K K, Park S M, Quon M J. Leptin and cardiovascu lar disease response to therapeutic intervention[J]. Circu lation, 2008,117 : 3238-3249.
  • 3Craig A, Lygate, Steffen Bohl, et al. Moderate elevation of intracellular creatine by targeting the creatine trans- porter protects mice from acute myocardial infarction[J]. Cardiovascular Research, 2012,96,466-475.
  • 4Hilzendeger A M, Morais,R L,Todiras M, et al. Leptin regulates ACE activity in mice[J]. J Mol Med, 2010,88 (9) :899-907.
  • 5Jeffrey P, Cardinale, Srinivas Sriramula. Angiotensin Ⅱ-Induced hypertension is modulated by nuclear factor- kB in the paraventricular nucleus [J]. Hpertention, 2012,59:113-121.
  • 6Gelosa P,Banfi C,Brioschi M. S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats by preserving mito- chondrial function [ J ]. Eur J Pharmacol, 2009,604 ( 1/3 ) : 117 - 124.
  • 7Morozova TE, Ivanova EP, Rykova SM. Clinico-economical aspects of application of trimetazidine MB in patients with chronic heart fail- ure and cardiac rhythm disturbances [ J]. Kardiologiia,2011;51 (9) :35 -41.
  • 8Kranstuber AL, Del Rio C, Biesiadecki B J, et al. Advanced gly- cation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling [ J ]. Front Physiol, 2012,19 (3) :292.
  • 9Boudina S, Sena S, O'Neill BT, et al. Reduced mitochondrial oxi- dative capacity and increased mitochondrial uncoupling impair myo- cardial energetics in obesity [ J ]. Circulation. 2005,112 ( 17 ) : 2686-2695.
  • 10Anderson E J, Kypson AP,. Rodriguez E, et al. Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human hear.[ J]. J" Am Coil Cardiol, 2009,54(20) : 1891-1898.

引证文献6

二级引证文献32

山东医药
2011年 第43期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部