血清超敏C-反应蛋白(hsCRP)与代谢综合征关系的研究

The relationship between high sensitivity C-reactive protein and metabolic syndrome

目的:探讨自然人群中超敏C-反应蛋白(hsCRP)与代谢综合征的关系。方法:在江苏省高邮市送桥镇随机入选609名18～74岁农村居民,使用标准流行病学调查表进行问卷调查,并测量血压,空腹抽血常规生化检查,免疫比浊法测量hsCRP。根据2004年国际糖尿病联盟(IDF)推荐的有关中国人代谢综合征(MS)的诊断标准诊断。结果:随着代谢综合征组分的聚集,男性与女性的hsCRP均有显著升高(校正后男性P=0.043,女性P=0.003)。校正年龄、吸烟史、饮酒史、服药史及心率后,logistic回归提示男性与女性hsCRP均与代谢综合征患病率独立相关(男性P=0.002,女性P=0.001),总人群进一步调整性别后,关系仍显著(P<0.0 1)。校正类似的变量后,偏相关分析显示,在总人群及各性别亚组中,腰围和甘油三酯均与hsCRP相关,而收缩压及高密度脂蛋白胆固醇仅在总人群及男性组中与hsCRP相关。结论:hsCRP与代谢综合征各组分及其患病风险独立相关。

Objective： To investigate the relationship between high sensitivity C-reactive protein（hsCRP） and metabolic syndrome in a general population.Methods： We randomly selected 609 subjects aged 18-74 years stratified by gender and age in Songqiao,a rural area of Jiangsu Province.A standardized questionnaire was used to collect information on medical history,smoking,alcohol intake and use of medications.Blood pressure was measured by mercury sphygmomanometer.Serum hsCRP concentration was measured using a high sensitivity BNprosec immunonephelometric assay.Metabolic syndrome was diagnosed according to the criterions of IDF（2004）.Results： With increasing number of the metabolic syndrome components,serum hsCRP concentration of both genders was increased significantly（for men,adjusted P = 0.043;for women,adjusted P = 0.003）.Logistic regression indicated that prevalence of metabolic syndrome was in proportion to increasing hsCRP levels（for total subjects,adjusted P 0.01;for men,adjusted P = 0.002;for women,adjusted P = 0.001）.In further partial correlation analysis,waist and serum triglycerides were found to be associated with hsCRP in total subjects and both genders,while systolic blood pressure and serum HDL cholesterol were related to hsCRP only in men.Conclusion： hsCRP was independently associated with both prevalence and individual components of metabolic syndrome in this study population.