左旋多巴醇在不对称还原中的应用研究

Applied Research on L-dopa Alcohol in Asymmetric Reduction

在NaBH4/Cd2+、NaBH4/Co2+、NaBH4/Ce3+、NaBH4/Ni3+还原体系中,采用加入手性源左旋多巴醇和不加入左旋多巴醇两种方法,分别对苯乙酮进行不对称还原,结果表明,加入手性源左旋多巴醇后,反应速度快,产率高。同时在这4种还原体系中NaBH4/Ce3+的催化效果最好。

Asymmetric reduction of acetophentone was prepared by two methods of adding L-dopa Alcohol or no adding L-dopa alcohol with NaBH4/Cd2＋ 、NaBH4/Co2＋ 、NaBH4/Ce3＋ 、NaBH4/Ni3＋ as the reducing agent.The optimum conditions were as followed： the method of adding L-dopa alcohol had the advantages of faster reaction speed and higher yield.At the same time,with NaBH4/Ce3＋ as the reducing agent was the best of catalytic effect in the four reduction system.