顽固性呃逆与菌群失调及真菌二重感染的相关性及其临床意义

Intractable hiccups and dysbacteriosis and fungal infection of relevancy double and their clinical significance

目的探究顽固性呃逆与菌群失调及真菌二重感染的相关性。方法对使用抗生素后发生顽固性呃逆的患者120例,首先均进行常规治疗,同时进行实验室真菌检查,根据真菌检查阳性与否分为A、B两组,其中真菌检查阳性组(A组)52例和真菌检查阴性组(B组)68例。对A组52例进行抗真菌药物治疗,根据抗生素是否继续使用再分A1、A2两组,其中继续抗生素加抗真菌药物治疗组(A1组)32例和停抗生素加抗真菌药物治疗组(A2组)20例;对B组68例再随机分为B1、B2两组,包括停抗生素加常规治疗组(B1组)34例和继续抗生素加抗真菌药物治疗组(B2组)34例。观察各组顽固性呃逆的疗效,以及各组之间的疗效对比,顽固性呃逆与抗生素、菌群失调及真菌二重感染的关系。结果常规治疗均效果不好,抗生素只能使顽固性呃逆病情加重,抗真菌药物治疗起效快,效果好,治愈率高达95%左右,有效率达100%。结论顽固性呃逆与使用抗生素引起的菌群失调及真菌二重感染有相关性,抗真菌药物治疗对终止顽固性呃逆疗效显著。

Objective To explore the crrelation of intractable hiccaps,dysbacteriosis and fungal nfection of relaevancy relevancy.Methods Using antibiotics intractable hiccups happened after 120 cases of patients with routine therapy,first of all,meanwhile,according to the laboratory fungi check whether fungal check divided into A positive,B two groups,including fungi check positive group（group A） 52 cases and fungal check negative groups 68 patients（group B）.Example of A group of 52 antifungal drugs antibiotic treatment,according to whether continue to use again cent A1,A2,which continue to two groups of antibiotics with antimycotic group（A1 group） 32 cases and stop antibiotics with antimycotic group（A2 group） 20 cases.B group 68 cases were randomly divided into B1,B2 again two groups,including stop antibiotics with conentional treatment group（B1 group） 34 patients and continue antibiotics with antimycotic group（B2 group） 34 patients.Observed the curative effect of each intractable hiccups,and between groups,the curative effect of intractable hiccups of antibiotics and contrast,dysbacteriosis and fungi double infection relations.Results Conventional treatments result was bad,antibiotics can only make intractable hiccups illness aggravating,antimycotic effect-acting fast,the effect was good,cure rate up to 95 percent or so,efficient,100%.Conclusion Intractable hiccups and use antibiotic bring the dysbacteriosis and fungal infection between the double,antimycotic intractable hiccups of termination curative effect is distinct.