血清维生素A与儿童1型糖尿病的相关性探讨

The relationship between serum concentration of vitamin A and type 1 diabetes mellitus in children

目的初步探讨血清维生素A水平与儿童1型糖尿病(T1DM)关系,了解糖化血红蛋白(HbA1c)、血清空腹C-肽与血清维生素A的相关性。方法选取32例T1DM患儿为T1DM组,28例健康体检儿童为对照组,用微量荧光方法检测两组血清维生素A水平,用化学发光法、激光散射比浊法分别测定32例T1DM患儿血清C-肽、HbA1c。结果 T1DM组血清维生素A水平明显低于对照组(P<0.01);T1DM组血清维生素A水平与空腹血清C-肽水平呈正相关(r=0.356,P<0.05),与HbA1c呈负相关(r=-0.394,P<0.05)。结论 T1DM患儿体内存在维生素A缺乏,维生素A水平低下可能与T1DM的发生有关。

Objective To explore the relationship between serum concentration of vitamin A and type 1 diabetes mellitus in children.Methods Totally 32 children with T1DM were taken as T1DM group,and 28 healthy children as normal control group.The serum concentration of vitamin A was determined by the method of micro-flourescence,and the serum level of C-peptide and the level of HbA1c were determined by the methods of chemoluminescence and laser nephelometry,respectively.Results The level of vitamin A in T1DM group was lower than that in control group（P〈0.01）.The serum concentration of vitamin A was positively correlated with the serum level of C-peptide in T1DM group（r=0.356,P〈0.05）,and negatively with the level of HbA1c（r=-0.394,P〈0.05）.Conclusion The deficiency of vitamin A is present in T1DM,and there is maybe relationship between the low serum level of vitamin A and the development of type 1 diabetes mellitus in children.