内分泌激素水平检测在垂体瘤治疗中的临床观察

Endocrine hormone levels detected in the clinical treatment of pituitary tumors in the clinical observation

目的探讨内分泌激素水平检测在垂体瘤临床治疗中的应用价值。方法回顾性分析我院2008年6月至2011年6月收治的112例垂体瘤切除手术患者的临床资料,观察并分析手术前后血清泌乳素(PRL)、生长激素(GH)、甲状腺功能(T3、T4)、促甲状腺素(TSH)、血皮质醇(F)和促肾上腺皮质激素(ACTH)的变化情况。结果垂体PRL和GH瘤患者术后的PRL和GH值低于术前(P<0.05),尤其是全切组(P<0.01);11例术前垂体功能低下患者,术后T3低于术前的正常值。结论手术治疗可明显改善垂体腺瘤患者术前高激素水平状态,垂体激素水平的动态监测可作为评估肿瘤手术切除程度重要指标,对垂体瘤的综合治疗有重要临床意义。

Objective Detection of hormone levels in the clinical treatment of pituitary tumors in the clinical application value.Methods A retrospective analysis of our hospital in June 2008,admitted in June 2011 of 112 cases of pituitary tumor resection surgery in patients with clinical data,observation and analysis before and after surgery serum prolactin（PRL）,growth hormone（GH）,thyroid function（T3,T4）,thyroid-stimulating hormone（TSH）,serum cortisol（F） and adrenocorticotropic hormone（ACTH） changes.Results Pituitary tumor patients PRL and GH pituitary tumors in patients with postoperative PRL and GH values less than preoperative（P〈0.05）,especially the full-cut group（P〈0.01）.11 patients with a preoperative pituitary dysfunction in patients after surgery than T3 before the normal.Conclusion Surgical treatment of pituitary adenomas can significantly improve the high hormone levels in patients with preoperative state,the dynamic monitoring of pituitary hormone levels can be assessed as an important indicator of the extent of tumor resection,the combined treatment of pituitary tumors has important clinical significance.