摘要
目的探讨NOB1 mRNA(nin one binding protein)在食管鳞癌(esophageal squamous cell carcinoma,ESCC)患者组织中的表达及其与临床病理参数之间的关系。方法运用RT-PCR方法检测19例ESCC患者癌组织及对应的癌旁组织中NOB1mRNA的表达情况,分析NOB1mRNA表达与临床病理参数的关系。结果 19例ESCC患者癌组织及相应癌旁组织中,均检测到NOB1基因mRNA的表达。NOB1mRNA在ESCC组织(1.2133±0.14)中的表达明显高于癌旁食管组织(0.7142±0.11)中的表达,差异有统计学意义(<0.05)。并且NOB1mRNA在ESCC组织中的表达与年龄、性别、侵犯深度、淋巴转移、分化程度及临床分期无明显相关性,组间比较差异无统计学意义(>0.05)。结论 NOB1mRNA在ESCC组织中高表达,可能与ESCC的发生发展相关。
Objective To explore the expression of NOB1 mRNA in human esophageal squamous cell carcinoma（ESCC）.Methods The expression of NOB1 mRNA in 19 cases of ESCC and the adjacent esophageal tissues was detected by reverse transcription polymerase chain reactions（RT-PCR）.The correlations of NOB1 expression to clinicopathologic features were analyzed in 19 cases of ESCC.Results The expression of NOB1 mRNA was detected in 19 cases of ESCC and the adjacent esophageal tissues.The expression level of thymosin NOB1 mRNA in ESCC tissues（1.2133±0.14）was markedly higher than that in adjacent esophageal tissues（P〈0.7142±0.11,0.05）.The expression level of NOB1 mRNA was not correlated with age,sex,invasive depth,histological grade,tumor differentiation and clinical stage（P〈0.05）.Conclusion Thymosin NOB1 may play a role in initiation and progression of ESCC.
出处
《解剖科学进展》
CAS
2011年第6期545-547,共3页
Progress of Anatomical Sciences
