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幽门螺杆菌相关性胃癌患者血清白介素-4和干扰素-γ变化 被引量：4

Changes of serum levels of Interleukin-4 and Interferon gamma in patients with Helicobacter pylori-associated gastric cancer
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摘要 目的观察幽门螺杆菌(Helicobacter pylori,H.pylori)相关性胃癌患者血清白介素-4(IL-4)和干扰素-γ(IFN-γ)含量的变化,以探讨H.pylori感染时宿主TH1/TH2细胞的免疫应答变化。方法采用酶联免疫吸附测定法测定7例H.pylori阴性胃癌患者和13例H.pylori阳性胃癌患者血清IL-4及IFN-γ的含量。结果 2组患者血清IL-4及IFN-γ含量差异均无统计学意义(P=0.897)。结论 H.pylori感染对胃癌患者TH1/TH2细胞的免疫应答无明显影响。 Objective To observe the changes of serum levels of Interleukin-4 （IL-4） and Interferon gamma （IFN-γ） in patients with Helicobacter pylori （ H. pylori） -associated gastric cancer to explore the change of TH1/TH2 immunologic response. Method Enzyme linked immunosorbent assay （ELISA） was employed to determine the levels of serum IL-4 and IFN-γ in 7 cases of gastric cancer without H. pylori infection and 13 cases of gastric cancer with H. pylori infection. Result No significant differences between the levels of serum IL-4 and IFN-γ were found between the two groups （ P = 0.897）. Conclusion H.pylori infection may not affect the TH1/TH2 immunologic response in patients with gastric cancer.
作者 江泳 杨清峰 张旭 张爽 周磊 刘伟 张群超
机构地区 安徽省蚌埠市第三人民医院
出处 《中国微生态学杂志》 CAS CSCD 2011年第11期1001-1002,共2页 Chinese Journal of Microecology
基金 蚌埠市科技局计划资助项目(200968)
关键词 幽门螺杆菌 免疫应答 白介素-4 干扰素-Γ 胃癌 Helicobacter pylori Immunologic response Interleukin-4 Interferon gamma Gastric cancer
分类号 R378.991 [医药卫生—病原生物学]
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共引文献48

同被引文献38

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中国微生态学杂志
2011年 第11期

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