异甘草酸镁治疗酒精性肝病疗效观察

Clinical observation of magnesium isoglycyrrhizinate in the treatment of patients with alcoholic liver disease

目的观察异甘草酸铗治疗酒精性肝炎的疗效。方法将175例酒精性肝病患者随机分为两组。对照组82例应用肌苷注射液、维生素C、还原型谷胱甘肽静脉滴注，1次／d，疗程为21d。治疗组93例在此基础上应用异甘草酸镁注射液150mg静脉滴注。观察症状、体征、肝功能变化及不良反应。结果治疗组有效率高于对照组（P〈0．05），治疗组肝功能改善情况优于对照组（P〈0．05），两组均未发现明显不良反应。结论异甘草酸镁可以显著改善酒精性肝炎患者的症状和肝功能，，临床应用安全有效。

Objective To observe the clinical efficacy of magnesium isoglycyrrhizinate in the treatment of patients with alcoholic liver disease. Methods One hundred and seventy - five patients with alcoholic liver disease were randomly divided into 2 groups. The controlled group was treated with vitamin C, inosine injection, reduced glutathione by intravenous drop once a day for 21 days. The treatment group was treated with 150 mg magnesium isoglycyrrhizinate on the basis of that. Symptoms, signs, hepatic function tests and adverse effect were observed. Results The im- provement of liver function indexes in the treatment group were better than that in control group （ P 〈 0.05）. And the total effective rate of the treatment group was also higher than that of the control group（ P 〈 0.05）. No side effects were observed in the two groups. Conclusions Clinical symptom and liver function were improve after treatment with magnesium isoglycyrrhizinate in patients with alcoholic liver disease. The drug is effective and safe.