抑郁症动物模型的转换研究

A Translational Research for Enhanced Clinical Validity of Mouse Models of Depression

据世界卫生组织预测,抑郁症将成为"2020年全球疾病负担"排名第二的重大疾病,防治抑郁症的创新药物研发已成为医药科学发展的重要内容。本文在总结近年来关于抑郁症临床治疗和抑郁症动物模型进展的基础上,围绕"如何提高抑郁症动物模型临床预测效度"这一亟待解决的问题,采用"转化医学"的研究模式,提出关于抑郁症动物模型转换研究的一些策略,以期能为建立临床预测效度高的抑郁症动物模型和创新抗抑郁药物研发的革命性突破奠定基础和提供思路。

According to the World Health Organization, major depression disorder is projected to reach second place as leading contributor to the global burden of disease by the year 2020. Despite the emergency need for better therapies of depression, and major advances in the understanding of the molecular basis of this disorder in recent years, efforts to discover and develop new drugs for major depression disorder ,especially those which might revolutionize disease treatment, have been relatively unsuccessful. An important reason for this is that it is exceedingly difficult to build an animal model that perfectly recapitulates the symptoms of depression in human patients. In order to enhance clinical validity of animal models of depression, we reviewed the recent animal models of depression and discussed its translational research here.