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化生性胸腺瘤1例报道并文献复习 被引量:2

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摘要 目的探讨化生性胸腺瘤(metaplastic thymoma)的临床与病理学特点。方法对1例少见的化生性胸腺瘤进行光镜下组织学检查,同时进行免疫组化标记CK(AE1/AE3)、vimentin、CD99、TdT、CD99、CD3、CD5、CD20、CD34、CD43、CD57、calretinin、VEGF及Ki-67,并复习相关文献。结果患者女性4,5岁,左侧纵隔有一包膜完整的肿块,组织学特征具有明显双相性分化的肿瘤,由互相盘绕的上皮岛和束状梭形细胞组成,并可见出血囊性变的区域。免疫组化染色上皮细胞区域:CK(AE1/AE3)强阳性,vimentin阴性;梭形细胞区域:vimentin弥漫阳性,CK(AE1/AE3)及EMA阴性,Ki-67增殖指数1%;间质淋巴细胞:CD3、CD5、CD20、CD43均阳性,TdT和CD99均阴性。结论化生性胸腺瘤是一种少见的交界性或低度恶性的肿瘤,根据组织学特征及免疫组化检测可做出明确诊断。
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2011年第11期1240-1242,共3页 Chinese Journal of Clinical and Experimental Pathology
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参考文献14

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二级参考文献44

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共引文献20

同被引文献23

  • 1金梅,刘标,王丽,许敬尧.化生性胸腺瘤临床病理分析[J].中华病理学杂志,2006,35(5):285-288. 被引量:14
  • 2方志欣,毛志福,林辉,韦海明.胸腺上皮肿瘤WHO新组织学分型与临床特征的相关性分析[J].广西医学,2006,28(10):1523-1525. 被引量:1
  • 3李旭,石怀银.化生性胸腺瘤1例[J].临床与实验病理学杂志,2007,23(2):252-253. 被引量:8
  • 4Suster S, Moran C A, Chan J K. Thymoma with pseudosarcoma- tous stroma: report of an unusual histologic variant of thymic epi- thelial neoplasm that may simulate carcinosarcoma[ J]. Am J Surg Pathol, 1997, 21(11) :1316 -23.
  • 5Travis W D, Brambilla E, Miiller-Hermelink H K, et al. World Health Organization classification of tumours pathology and genet- ics. Tumours of the lung, pleura, thymus and heart [ M ]. Lyon : LARC Press, 2004:146-7.
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  • 7Yoneda S, A Marx A, Miiller-Hermelink H K. Low-grade meta- plastic carcinomas of the thymus : biphasic thymic epithelial tumors with mesenchymal metaplasia-an update [ J ]. Pathol Res Pract, 1999,195(8) :555 -63.
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  • 9Moritani S, Ichihara S, Mukai K, et al. Sarcomatoid carcinoma of the thymus arising in metaplastic thymoma [ J ]. Histopathology, 2008,52(3) :409 - 11.
  • 10Poorabdollah M, Mehdizadeh E, Mohammadi F, et al. Metaplastic thymoma: report of an unusual thymic epithelial neoplasm arising in the wall of a thymic cyst [ J]. Int J Surg Pathol, 2009,7 ( 1 ) :51 -4.

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