胸腺瘤完整切除术后辅助放疗效果系统评价

A Meta-analysis on Effects of Adjuvant Radiotherapy after Radical Resection of Thymoma

目的系统评价胸腺瘤完整切除术后放疗对患者生存率和复发率的影响。方法计算机检索EMBASE(1953—2010),CLINAHL(1953—2009)和MEDLINE(1953—2009),对符合纳入标准的临床对照试验,采用RevMan 4.3软件进行Meta分析。结果 7个临床对照试验,738例胸腺瘤患者,Meta分析表明,胸腺瘤完整切除术后放疗组与不放疗组的复发率差异无统计学意义(P=0.61),合并比值比(OR)及其95%可信区间(95%CI)为1.36(0.42,4.46),而且放疗组与不放疗组间生存率也没有统计学意义(P=0.16),合并比值比(OR)及其95%可信区间(95%CI)为1.45(0.86,2.44)。结论胸腺瘤完整切除术后辅助放疗并没有减少复发率和提高生存率,不需要常规应用。

Objective Our goal was to evaluate whether patients with completely resected thymoma were able to benefit from postoperative radiotherapy.Methods Three databases（including EMBASE,CINAHL,and MEDLINE） were searched as well as reference lists of articles and contacted authors were screened.Randomized controlled trails and controlled clinical trials were identified.Data were estimated with the Cochrane collaboration＇s RevMan 4.3 software.Results Seven controlled clinical trials involving 740 patients were included.Meta-analysis showed that there were no significant differences in recurrence rates and survival rates between radiantion group and no radiantion group,OR=1.36,95% CI（0.42,4.46）,P=0.61,and OR=1.45,95% CI（0.86,2.44）,P=0.16,respectively.Conclusion The adjuvant radiotherapy after complete resection of thymoma was albe to reduce the recurrence rates or improve the survival rates,and should not used routinely for patients after complete resection.