谷胱甘肽S转移酶P1 Ile105Val多态性与肺癌易感性关系的Meta分析

A Meta Analysis on Relationship between GSTP1 Ile105Val Genetic Polymorphisms and Lung Cancer Risk

目的用Meta分析的方法综合评价谷胱甘肽S转移酶P1基因(GSTP1)105氨基酸位点Ile/Val多态性与肺癌易感性的关系。方法检索公开发表的关于谷胱甘肽S转移酶P1基因105氨基酸位点Ile/Val多态性与肺癌易感性关系的文献,把研究人群分为高加索人群及东亚人群,以病例组及对照组比值比(OR值)为效应指标,应用Meta分析软件RevMan 4.2分别计算两种人群及其亚组的合并OR值及95%CI,进行敏感度分析和发表偏倚评估,给出Meta分析森林图和漏斗图。结果共纳入文献24篇,其中高加索人群15篇,纳入病例6 601例,对照6 821例,东亚人群9篇,纳入病例1 822例,对照2 017例,分别计算两组人群及其各亚组的GG+AG/AA合并OR值,两种人群总体OR值及各亚组OR值均未提示有相关性,敏感度分析表明结果稳定,高加索人群研究有发表偏倚,东亚人群研究未见发表偏倚。结论谷胱甘肽S转移酶P1基因(GSTP1)105氨基酸位点Ile/Val多态性与高加索人群和东亚人群肺癌易感性均不具有相关性,但是没有根据吸烟量进行亚组分析。

Objective To study the relationship between glutathione-S-transferase P1（GSTP1） Ile/Val genetic polymorphisms and lung cancer risk.Methods Documents were collected from databases.Study population were stratified by the ethnicity into Caucasians and the East-Asians.The Meta-analysis was analyzed by RevMan software 4.2 to evaluate the risks（the odds ratio and 95% CI）for the overall or the subgroups.The sensitivity analysis and publication bias were evaluated.The forest plot and funnel plot of meta-analysis were indentified.Results A total of 6 601 cases and 6 821 controls from 15 studies were Caucasians and a total of 1 822 cases and 2 017 controls from 9 studies were East-Asians.The pooled OR for the overall or the subgroups of the 2 populations indicated no association.The sensitivity analysis indicated the outcome was stable.Publication bias existed in the studies for Caucasian,but in the East-Asians.Conclusion This study indicates that the genetic polymorphism of GSTP1 Ile/Val was associated with the risks of lung cancer for neither Caucasians nor East-Asians,but subgroup analysis about smoking amount still required to be done.