P-ERK及MMP-2在宫颈癌组织中的表达及临床意义

Expression and Clinical Significance of P-ERK and MMP-2 in Cervical Cancer

目的 探讨细胞外信号调节激酶（P-ERK）及基质金属蛋白酶2（MMP-2）在宫颈癌中的表达及临床意义.方法 采用免疫组织化学SP法检测80例宫颈鳞癌、30例宫颈腺癌、30例宫颈原位癌和20例正常宫颈组织（对照组）中P-ERK及MMP-2的表达,分析其与宫颈癌患者临床病理特征之间的关系,并对两者进行相关性分析.结果 宫颈癌组P-ERK和MMP-2阳性表达率显著高于原位癌组和对照组;宫颈癌组不同组织类型、分化程度及有无淋巴结转移之间比较,P-ERK和MMP-2的阳性表达率均有显著性差异（P＜0.05）,且二者表达强度呈显著正相关（P＜0.05）.结论 P-ERK和MMP-2过表达可能与宫颈癌的发生、发展有关,二者联合检测可能作为评估宫颈癌恶性程度、判断预后及指导治疗的重要参考指标.

Objective To explore the expression and clinical significance of extracellular signal-regulated kinase（P-ERK） and matrix metalloproteinase-2 （MMP-2） in cervical cancer. Methods SP immunohistochemical technique was used to detect the expression of P-ERK and MMP-2 in 80 cases of squamous carcinoma of the cervix ,30 cases of adenoearcinoma of the uterine cervix ,30 eases of cervical car-cinoma in situ and 20 cases of normal cervical tissue（ control group）. Correlation was analyzed between P-ERK and MMP-2 expression in cervical cancer tissues. Results The positive rates of P-ERK and MMP-2 were higher in cervical cancer group than in cervical carcinoma in situ group and control group（ P 〈 0.05 ）. In cervical cancer group,there were also significant differences in P-ERK and MMP-2 positive expression rates among the different pathological grades, among the different histologieal types and between the different lymph node involvement （ P 〈 0. 05 ）. There was positive correlation between the expression of P-ERK and MMP-2 in cervical Cancer tissues （ P 〈 0.05 ）. Conclusion The excessive expression of P-ERK and MMP-2 is associated with the occurrence and develnpment of cervical cancer. The combined detection of P-ERK and MMP-2 may be used as important index to evaluate the degree of malignauce,judge prognosis and direct treatment for cervical cancer.