小剂量红霉素对9例弥漫性泛细支气管炎患者肺功能及影像学作用的回顾性分析

Retrospective analysis of effect of low-dose erythromycin therapy on lung function and radiology in patients with diffuse panbronchiolitis

目的探讨小剂量红霉素对弥漫性泛细支气管炎肺功能及影像学的作用。方法回顾性分析2008年至2010年入住我院呼吸科9例弥漫性泛细支气管炎患者资料，比较小剂量红霉素治疗3～6个月前后肺功能及其影像学改变的情况。结果治疗后肺功能检查第1秒用力呼气量（FEV。）占预计值％（81．39％±4．68％vs78．27％±4．98％）、用力肺活量（FVC）占预计值％（80．93％±5．46％vs76．59％±5．57％）、FEV1／FVC（65．34％±3．36％vs64．70％±3．43％）、呼出75％肺活量时的用力呼气流速占预计值％（47．54％±5．71％vs42．76％±3．79％）较治疗前升高（P〈0．05或P〈0．01），而残气量／肺总量较治疗前显著下降（46．74％±2．87％vs49．86％±3．25％）（P〈0．01）。结论小剂量红霉素能有效改善弥漫性泛细支气管炎的肺功能，减轻气流阻塞和气体的陷闭，与此同时能改善与小气道阻塞相关的影像学改变。

Objective To investigate the effect of low-dose erythromythin on lung function and radiology in patients with diffuse panbrochiolitis （DPB）. Methods The data of nine patients with DPB hospitalized in respiratory department were collected and analyzed retrospectively. The changes of lung function and radiology after treatment with low-dose erythromythin were compared with pre-treatment. Results Compared with pre-treatment, after therapy, the predicted percentage of forced expiratory volume in one second （FEVI）（81.39%±4.68% vs 78.27%±4.98%）, the predicted percentage of forced vital capacity （FVC） （80.93%±5.46% vs 76.59%%5.57%）, the ratio of FEV1 to FVC （65. 34 % ± 3. 36 % vs 64.70 % ± 3.43 % ） and the predicted percentage of forced expiratory volume with 75% vital capacity （47.54%±5.71% vs 42.76%%3.79%） has been increased （ P 〈0.05）. The ratio of residual volume to total lung capacity （46.74%±2.87% vs 49.86%±3.25%） decreased markedly （ P 〈 0.01）. Conclusions Low-dose erythromythin can improve the lung function of the patients with DPB efficiently to alleviate the obstruction of small airway and gas trapping, and improve the change of radiology correlated with the small airway obstruction.