摘要
细胞因子信号转导抑制因子1(suppressor of cytokine signaling-1,SOCS1)能反馈性抑制干扰素、白介素4等多种细胞因子的信号转导,在转录、翻译、蛋白各水平受到精密调控。适当的SOCS1表达可抑制哮喘的炎症反应,但不恰当的SOCS1表达可能增加发生哮喘的几率。在肺部感染中,SOCS1能防止机体出现过度的炎症反应,但也会降低机体清除病原的能力。SOCS1介导了白介素6减轻高浓度氧引起急性肺损伤的作用;特发性肺纤维化可能与SOCS1的低表达有关,转染SOCS1可抑制博莱霉素所致的肺纤维化。SOCS1与多种肺部疾病密切相关,但其精密调控的全景及意义还有待阐明。
Suppressor of cytokine signaling 1 (SOCS1) is a negative feedback regulator of cytokine signaling, such as interferon,interleukin-4. SOCS1 is regulated on transcription, translation and protein level. Appropriate SOCS1 expression can attenuate the inflammation in asthma, while inappropriate SOCS1 expression may increase the morbidity of asthma. SOCS1 can prevent lethal inflammation in lung infection, while it can also compromise pathogen eradication. SOCS1 mediates the interleukin-6 cyto-protection in hyperoxic acute lung injury. Idiopathic lung fibrosis and aberrant collagen production may be linked to diminished SOCS1 expression, and SOCS1 can suppress the lung fibrosis induced by bleomycin. In conclusion, SOCS1 plays an important role in many lung diseases, but the panorama and significance of SOCS1 regulation still remain to be elucidated.
出处
《国际呼吸杂志》
2011年第21期1659-1662,共4页
International Journal of Respiration
基金
上海市科委生物医药重点课题(09411951400)