帕瑞昔布钠用于直肠癌患者术后镇痛的临床研究

Postoperative analgesic effect of parecoxib sodium in patients with carcinoma of rectum

目的观察帕瑞昔布钠在直肠癌患者术后镇痛的临床疗效和不良反应。方法将全麻下行直肠癌根治术患者180例随机分为帕瑞昔布钠组和对照组,每组90例,双盲对照观察。手术结束前30min帕瑞昔布钠组患者静脉注射帕瑞昔布钠40mg,对照组静脉注射生理盐水2mL;术后6、12、24、48h观察视觉模拟评分法(visual analogue scale,VAS)评分、不良反应发生情况和患者满意度。结果帕瑞昔布钠组术后6、12、24、48hVAS评分明显小于对照组(P<0.05)。结论直肠癌术后短期应用帕瑞昔布钠镇痛,可为患者提供良好的镇痛效果。

Objective To observation the postoperative analgesic effect and adverse reactions of parecoxib sodium in patients with carcinoma of rectum.Methods 180 patients aged 52 to 72 years undergoing rectum cancer surgery under general anesthesia were randomly divided into parecoxib sodium group（n=90） and placebo group（n=90）.The patients in parecoxib sodium group were given 40 mg parecoxib sodium intravenously 30 min before the completion of surgery,and the placebo group received intravenously saline 2 mL at the same time points.At 6,12,24 and 48 h after the operation,the VAS score,patient satisfaction and adverse reactions were recorded after the administrations.Results Compared with the placebo group,the patients in parecoxib sodium group had significantly lowered VAS score at 6,12,24 and 48 h after the operation（P0.05）.Conclusion Postoperative short-term use of parecoxib sodium can provide good postoperative analgesic effect in patients undergoing rectum cancer surgery.