质子泵抑制剂研究新进展

Recent Progress in Research on Proton Pump Inhibitors

质子泵抑制剂是一类用于治疗胃、十二指肠溃疡,反流性食管炎和卓-艾综合征等酸相关性疾病的抑酸药物,且具抗氧化、抗炎、抗凋亡及抗癌等多重药理活性。综述质子泵抑制剂的分子作用机制、药理作用和药动学特性及其影响因素,并介绍若干新型质子泵抑制剂。

The proton-pump inhibitors（PPIs） are considered as a class of therapeutic agents for a variety of acid-related disease,such as gastric and duodenal ulcer,reflux esophagitis,Zollinger-Ellison syndrome,and so on.They have shown multiple pharmacological activities,such as antioxidation,anti-inflammation,anti-apoptosis and anti-cancer.PPIs′ molecular mechanism,pharmacological action,pharmacokinetics and the influencing factors thereof were reviewed.Some novel PPIs were also introduced in this paper.