MDM2/p53通路与心血管疾病的研究进展

The Research Progress of Mdm2/p53 Pathway and Cardiovascular Disease

鼠双微基因2(MDM2)是一原癌基因,因mRNA的不同剪切可形成多种不同相对分子质量的变异体,如p57、p64、p85、p90等。在正常细胞中,MDM2和野生型p53有着精细的平衡,其相互调节形成负反馈回路:p53诱导MDM2表达,MDM2与p53结合形成p53-MDM2复合物,使p53泛素化而被蛋白酶降解。MDM2-p53反馈体系与其他信号转导途径一起形成调控网络,参与细胞生长抑制、凋亡、细胞周期调控等各种生物进程。现对MDM2/p53途径在心血管疾病中的研究进展进行综述。

Murine double minute 2（Mdm2）gene is an oncogene,due to the different cuttings of mRNA,a variety of variants with different molecular weight can be formed,such as p57,p64,p85,p90 and so on.In normal cells,Mdm2 and wild-type p53 has a delicate balance.The Interaction between them form a negative feedback loop：p53 induces the expression of Mdm2,the combination of Mdm2 and p53 forms a compound named p53-Mdm2.It makes p53 to be ubiquitinationed and then degraded by protease.Regulatory networks formed by Mdm2-p53 feedback system and other signaling pathways involved in cell growth inhibition,apoptosis,cell cycle regulation and other biological processes.Here is to review the progress of the Mdm2/p53 pathways in cardiovascular disease research.