氧自由基与高原病研究进展

The Research Progress of Oxygen Free Radicals and Altitude Disease

高原地区缺氧低压等因素,易引起高原病的发生。高原病发生机制复杂,近年来研究热点多集中在对氧自由基的研究。高原缺氧环境下,能量代谢障碍、紫外线辐射量增加等因素导致机体氧化和抗氧化失衡,氧自由基增多。过多的氧自由基又可损伤生物膜,引起蛋白质变性和DNA突变,甚至干扰细胞信号转导,引起细胞凋亡,影响组织细胞功能,最终引起高原病的发生。因此,氧自由基可能是引起高原病发生的重要中介因素,研究氧自由基与高原病的关系,可为今后高原病的防治工作提供新思路。

Hypoxia,low pressure and other factors in plateau could easily cause the occurrence of altitude disease.Research in recent years,mostly concentrated in the study of oxygen free radicals,despite of complex mechanisms of altitude disease.In high altitude environment,energy dysbolism,increased ultraviolet radiation and other factors lead to oxidation and antioxidant imbalance in the body and then the increasing of oxygen free radicals.The excess of oxygen free radicals can damage biofilm,cause protein denaturation and DNA mutation,and even interfere with cell signal transduction and cause cells apoptosis,which will all affect tissue and cell function and ultimately induce altitude disease.Therefore,oxygen free radicals may be an important mediating factor in the occurrence of altitude disease,the study on the correlation will provide new ideas for future prevention and treatment of the disease.