肝癌DNA甲基化的研究进展

Research Progress in DNA Methylation of Hepatocellular Carcinoma

肝癌的发生同其他人类肿瘤一样,都是由表观遗传学异常和基因改变共同引起,DNA甲基化是表观遗传学上研究最为深入的一种机制。在肝癌的发生发展过程中,抑癌基因等肿瘤相关基因的高甲基化和整个基因组水平的低甲基化起着重要作用,肝癌的甲基化研究对肝癌的早期诊断和病情预后的监测及其防治具有重要意义。在此对肝癌DNA甲基化特征及其临床意义进行阐述。

The development of hepatocellular carcinoma（HCC）,like other tumors,is induced by epigenetic alterlations and genetic mutation,DNA methylation is the mechanism of epigenetics with most in-depth research so far.Hypermethylation of tumor-related genes such as tumor suppressor genes and hypomethylation of the total genome play important roles in the hepatocarcinogenesis.The study of methylation is proved to be of considerable value for early diagnosis and prognosis monitoring,prevention and treatment of hepatocellular carcinoma.Here is to discuss the DNA methylation features of hepatocellular carcinoma and the clinical value.