功能性消化不良发病机制的研究进展

Research Progress in Pathogenesis of Functional Dyspepsia

功能性消化不良(FD)是临床上最常见的一种功能性胃肠病,其发病机制至今尚不清楚。目前多数认为与胃肠运动障碍、内脏敏感性增加、幽门螺杆菌感染、胃肠激素、精神心理因素等有关,但任何一种发病学说都无法概括该病的全部临床表现。目前一致观点认为,此病是多种发病机制共同参与和共同作用的结果,脑-肠轴以及其相关的胃肠激素备受关注。现就近年来有关FD的发病机制的研究进展作一综述,着重论述胃肠激素在FD中的作用。

Functional dyspepsia（FD）is the most common form of clinical functional gastrointestinal diseases,and its pathogenesis is still unclear.Currently the major view is that FD is correlated with gastrointestinal motility disorders,visceral sensitivity increase,helicobacter pylori infection,gastrointestinal hormones,and mental psychological factors etc.,however none of the theories can cover all the clinical manifestations of the disease.It is now agreed that the the disease is the result of multiple pathogenesis,and the brain-gut axis and its related gastrointestinal hormones are drawing much attention.Here is to review the recent progress in pathogenesis of FD with emphasis on gastrointestinal hormones roles.