重组人生长激素对不同青春期特发性矮小症疗效研究

Study of Recombinant Human Growth Hormone′s Curative Effects on Puberty Idiopathic Short Stature

目的探讨重组人生长激素对不同青春期时期特发性矮小症(ISS)患儿的疗效。方法应用重组人生长激素治疗青春期不同时期ISS患儿6个月,比较三组患儿治疗前后生长发育、血糖、甲状腺功能和血胰岛素样生长因子1及胰岛素样生长因子结合蛋白3的差异。结果三组ISS患儿治疗后的身高、体质量、生长速度和骨龄较治疗前增加,其中在身高和生长速度方面的差异具有统计学意义(P<0.05)。青春期前期组ISS患儿治疗后的生长速度改善显著高于青春期中期组和后期组患儿(P<0.05)。三组ISS患儿治疗前后的血糖和甲状腺功能均处于正常状态,且三组间血糖和甲状腺功能无明显差异(P>0.05)。三组患儿治疗后的血胰岛素样生长因子1和胰岛素样生长因子结合蛋白3浓度较治疗前均显著增加(P<0.05),其中青春前期组患儿改善程度显著高于青春期中期组和后期组(P<0.05)。结论重组人生长激素对青春期前期ISS患儿疗效最好,ISS患儿应早期治疗。

Objective To study recombinant human growth hormone′s curative effects on idiopathic short stature（ISS）in different puberty stages.Methods Children with ISS in different puberty stages were treated for 6 months with recombinant human growth hormone.Growth,blood glucose,thyroid function,insulin-like growth factor 1 and insulin-like growth factor binding protein 3 were compared.Results The height,weight,growth velocity and bone age were significantly promoted especially 3 months after treatment.The promotions in pre-puberty group were significantly higher than that in mid-puberty and post-puberty groups（P0.05）.The blood glucose and thyroid function were not significant pre-puberty and post-treatment in three groups（P0.05）.Blood insulin-like growth factor 1 and insulin-like growth factor binding protein 3 significantly increased especially in pre-puberty group（P0.05）.Conclusion Recombinant human growth hormone has the best curative effects on pre-puberty children with ISS.Children with ISS should be treated in early stages.