诺雷德对乳腺癌化疗患者月经复潮影响的临床研究

Effect of Zoladex Administered before Chemotherapy on Menstruation of Patients with Breast Cancer

目的:观察诺雷德对进行术后辅助化疗并且有维持正常月经要求女性,保护月经复潮的影响。方法:对确诊为乳腺癌并有维持正常月经要求的女性患者随机分成试验组(应用诺雷德+常规化疗组)和对照组(常规化疗组),比较2组患者化疗后的月经来潮情况。结果:21例乳腺癌患者均可完成治疗,化疗后月经周期紊乱。试验组、对照组复潮人数72.7%:50%,P=0.039<0.05,统计学有明显意义。结论:常规化疗会导致患者提前永久性闭经,月经恢复与年龄相关,化疗前应用诺雷德,可以有效地保护其卵巢功能,保证了患者要求维持正常月经的可能。

Objective： To observe the effect of Zoladex being used to protect the ovarian function in the patients with breast cancer requiring for fertility or/and maintenance of the normal hormone level before chemotherapy. Methods： Patients with breast cancer requiring for fertility or/and maintenance of the normal hormone level were randomly divided into the test group and the control group. We compared the menstruation status after the chemotherapy between the two groups. Results：All of these 21 breast cancer patients completed the treatment.The rates of the return of menstruation in the test group and the control group were 72.7% and 50% ,respectively （P=0.039）.Conclusions： Conventional chemotherapy may lead to permanent amenorrhea in advance and the recovery of menstruation is age-related. Zoladex administered before chemotherapy can effectively protect the ovarian function and can satisfy the patients with breast cancer requiring for fertility or / and maintenance of the normal hormone level.