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过氧化物酶体增殖因子激活受体α激动剂抗肿瘤的研究进展

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摘要 1 PPARα的结构和特性 PPARα是第1个被鉴别出来 PPAR的亚型[1],人 PPARα（NR1C1）位于22号染色体长臂（22q12-q13.1）,长约93.2 kb,编码的mRNA包含8个外显子,第1、2外显子和部分3外显子编码5＇非翻译区,第8外显子的后232个碱基编码3＇非翻译区,其余的是翻译区,编码468个氨基酸组成的蛋白,相对分子质量为55 000 .基因结构上有A、B、C、D、E、F结构域,按功能分为4个域：A/B结构域、DNA结合结构域（C）、铰链结构域（D）和配体结合结构域（E/F）.A/B结构域、E/F结构域中分别包含激活功能结构域1（activation function 1,AF1）、激活功能结构域2（activation function 2,AF2）结构域.
作者 刘春妮 曾锦荣
机构地区 桂林医学院附属医院呼吸内科
出处 《重庆医学》 CAS CSCD 北大核心 2011年第33期3415-3418,共4页 Chongqing medicine
基金 广西卫生厅医疗卫生重点科研课题资助项目(重2010046)
关键词 过氧化物酶体增殖物激活受体 激动剂 抗肿瘤 机制
分类号 R96 [医药卫生—药理学]
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参考文献33

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重庆医学
2011年 第33期

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