尼尔雌醇治疗D-炔诺孕酮埋植剂致月经紊乱临床分析

Effect of nylestriol in treatment of norplant-induced menstrual disturbance

目的：治疗D-炔诺孕酮埋植剂（Norplant）皮下埋植术后的副作用——月经紊乱。方法：接受Norplant避孕术后月经紊乱的292例患者按临床症状随机分两组,分别用尼尔雌醇、6-氨基己酸治疗。结果：尼尔雌醇组调经、止血效果明显优于6-氨基己酸组,且疗程短、复发率低。统计学处理两组有显著性差异（P〈0.01）。结论：Norplant致月经紊乱与卵巢功能、雌孕激素水平有关。用尼尔雌醇治疗,可减轻不良反应,治疗月经紊乱,降低取出率和提高使用率。

Objectives： To observe the effect of nylestriol in the treatment of norplant-induced menstrual disturbance.Methods： Two hundred and ninety-two patients who suffered from menstrual disturbance after norplant contraception were randomly divided into the experiment group and the control group.Nylestriol was applied to the experiment group while 6-aminocaproic acid applied to the control.Results： The experiment group showed significantly better effects than the control group in menstruation normalization and hemostatis（P0.01）.In addition,nylestriol took shorter treatment course and revealed lower recurrence rate.Conclusion： Norplant-induced menstrual disturbance is related to ovarian function and estrogen,progesterone levels.Nylestriol can effectively reduce the side effects of norplant and treat menstrual disturbance.