疲劳安口服液对CFS大鼠行为学的影响

The Effects of Pilaoan Oral Liquid on Behavioristics of CFS Rats

目的观察疲劳安口服液对慢性疲劳(CFS)模型大鼠行为学的影响,探讨疲劳安口服液对CFS模型大鼠的治疗效果及其作用机制,为临床用药提供依据。方法采用复合刺激建立CFS大鼠模型,观察各组大鼠用药前后在水迷宫实验、负重力竭游泳实验、敞箱实验中的行为学变化。结果疲劳安口服液可显著延长模型组动物冷水游泳至力竭的时间,穿格次数明显增加,在水迷宫中找到目标区的时间明显缩短。结论疲劳安口服液可显著改善CFS大鼠的行为状态。

Objective To observe the effects of Pilaoan oral liquid on behavioristics of rats with chronic fatigue syndrome（CFS）,to study its treatment effects and mechanism on CFS rats,and to provide basis for clinical administration.Methods CFS rats model was made with multiple stimuli.Rats＇ behavioristic changes in water maze experiment,weight-bearing exhaustive swimming experiment and open field test.Results Pilaoan oral liquid could obviously prolong the time of swimming till exhaustion,improving the times of crossing latticework,and shorten the time for finding the object in water maze.Conclusion Pilaoan oral liquid can significantly improve CFS rats＇ behavioristics.