抗风湿涂膜剂的制剂研究

Preparation research of fights rheumatism paints

研究氮酮和丙二醇在不同体积分数下,对辣椒素和川乌总生物碱的促透影响以及涂膜剂的基质选择.应用改良Franz扩散池装置,通过HPLC法对辣椒素和酸性染色比色法对对川乌总生物碱进行含量测定,对比不同比例的氮酮和丙二醇对它们的促透效果;根据外观透明度﹑黏稠性和成膜性等确定基质壳寡糖的加入量.氮酮和丙二醇不同组合对辣椒素的促透效果差异明显,而对于川乌总生物碱效果不明显.综合考虑,体积分数1%氮酮和体积分数6%丙二醇联合应用对辣椒素和川乌总生物碱的促透效果最好;加入10倍于成分药药量的壳寡糖制剂效果最好.

To research that the azone and propylene glycol at different concentrations on promoting penetration effects of capsaicin and the total alkaloids in radix aconite and the matrix of choice about paints.Using modified Franz diffusion cells,determination of contents of capsaicin were assayed by HPLC,determination of contents of the total alkaloids in Radix Aconiti were assayed by acid dyeing colorimetry.The contrast between azone and the propylene glycol at different contents with capsaicin or the total alkaloids in Radix Aconiti on promoting percutaneous absorption.According the transparency,viscosity and into the membranous to determine addition amount about the matrix-shell of oligo.There were significant differences between azone and propylene glycol at different contents with capsaicin,but it was not obvious with the total alkaloids in Radix Aconiti.The effect of 1%（V/V） azone and 6%（V/V）propylene glycol on promoting percutaneous absorption of capsaicin and the total alkaloids in Radix Aconiti was the best.The best effect was matrix-shell of oligo that add 10 times the composition medicine dose.