伊布利特对老年心房颤动患者转复的疗效和安全性观察及护理

Observation of the efect and nursing of ibutilide for conversion of atrial fibrillation in old patients

目的观察伊布利特对老年心房颤动患者转复的有效性和安全性,总结围转复期的护理经验,以便更安全的应用伊布利特。方法将90例心房颤动老年患者随机分为2组,其中伊布利特组54例给予静脉注射伊布利特进行心律转复;普罗帕酮组36例给予静脉应用普罗帕酮进行心律转复,严密观察转复过程中的心电图、血压情况,比较2组药物对不同病程心房颤动患者转复成功率的影响,并观察转复过程中的不良反应。结果伊布利特组对不同病程组患者转复的成功率显著高于普罗帕酮组,差异有统计学意义(P<0.05)。2组不良反应均较轻微。结论对于老年心房颤动患者,伊布利特是相对安全有效的转复药物之一,严格把握适应证和禁忌证并严密观察能够有效减少不良事件的发生。

Objective To evaluate the efficacy and safety of ibutilide for conversion of atrial fibrillation in old patients and find out nursing measures for coping with the disease safely use of ibutilide. Methods 90 cases elderly patients with atrial fibrillation were randomly divided into two groups, which ibutilide group of 54 cases patients were given intravenous ibutilide cardioversion for rhythm ; Propafenone group of 36 cases patients were given intravenous propafenone eardioversion for rhythm, closely observed the process of re-turn the ECG,blood pressure, compared drugs on the different course of patients with atrial fibrillation eardioversion success rate of two groups,and observed the process of re-turn of adverse reactions. Results Cardioversion success rate of patients with different duration in ibutilide group were significantly higher than those in propafenone group, the difference were statistically significant （ P 〈 0.05 ）. Adverse reactions of two groups were mild. Conclusion For elderly patients with atrial fibrillation,ibutilide is relatively safe and effective transfer of complex drugs. To master the indication and contraindicatin strictlv and observe exactlv can effectlv decrease the bad events.