经鼻持续正压与机械通气治疗极低出生体质量儿呼吸衰竭的疗效比较

A comparison of the nasal continuous positive airway pressure and mechanical ventilation for the very low birth weight infants with breathe failure

目的比较呼吸衰竭极低出生体质量儿,应用经鼻持续正压(nCPAP)和常规机械通气(conventional mechanical ven-tilation,CMV)治疗,比较两组的疗效。方法将32例呼吸衰竭极低出生体质量儿随机分为两组:nCPAP组16例,机械通气组16例,观察两组的治愈率、上机时间和并发症发生情况。结果 nCPAP组与机械通气组治愈率无显著差异(P>0.05),nCPAP组上机时间较机械通气组显著缩短(P<0.05),两组并发症发生率有显著差异(P<0.05),机械通气组并发症明显增多。结论呼吸衰竭极低出生体质量儿使用nCPAP,能减少机械通气的使用率,降低各种并发症,提高极低出生体质量儿的生存质量。

Objective To compare the outcome of the very low birth weight infants with breathe failure who were extubated to nasal continuous positive airway pressure（nCPAP） and continued on conventionical mechanical ventilation（CMV）.Methods Thirty-two very low birth weight infants with breathe failure were randomized to either nasal continuous positive airway pressure（nCPAP group,n=16）or continued on conventionical mechanical ventilation（CMV group,n=16）,observing curative rate,the time of ventilator,the secondary outcome.Results There were no significant differences in curative rate between infants in CMV group and nCPAP group（P0.05）.The time of ventilator was significantly shorter in the nCPAP group（P0.05）.There was significant differences in curative rate between infants in CMV group and nCPAP group（P0.05）.There was significant increase in the secondary outcome in CMV group.Conclusion The very low birth weight infants with breathe failure with extubation to nCPAP could had a shorter duration of oxygen,less secondary outcome as compared to CMV.nCPAP can improve existence quality of the very low birth weight infants.