期刊文献+

超声微泡及其在分子影像诊断和靶向治疗中的应用 被引量:1

Ultrasound Microbubble and Its Application in Molecular Imaging Diagnosis and Targeted Therapy
下载PDF
导出
摘要 超声微泡是一种超声造影剂,利用超声微泡声学特征和靶向功能可提高超声分子诊断的灵敏性和特异性,利用其药物载体和释放功能可进行靶向药物治疗。现对超声微泡及其在分子影像诊断和靶向治疗中的应用进展作一综述。 Ultrasound microbubble is a kind of ultrasound contrast agents(UCA).Using the acoustic features and target function of ultrasound microbubble,the sensitivity and specificity of ultrasound molecular diagnosis can be improved.Using its drug carrier and release function,target drug therapy can be implemented.The progress of ultrasound microbubble and its application in molecular imaging diagnosis and targeted therapy are reviewed.
出处 《现代诊断与治疗》 CAS 2011年第6期353-357,共5页 Modern Diagnosis and Treatment
关键词 超声微泡 分子影像诊断 靶向治疗 Ultrasound microbubble Molecular imaging diagnosis Targeted therapy
  • 相关文献

参考文献32

  • 1Weissleder R. Ultrasound U molecular imaging[ J ]. Radiology ,2001,219 (2) :316-333.
  • 2Tinkov R, Bekeredjian G, Winter C, et al. Microbubbles as ultrasound triggered drug carriers [ J ]. Pharm Sci ,2009,98 ( 6 ) : 1935-1961.
  • 3王志刚.超声造影剂基础研究现状与进展[J].中华医学超声杂志(电子版),2011,8(5):924-928. 被引量:31
  • 4Alkan-Onyuksel H, Demos SM, Lanza GM, et al. Development of inherendy echagenic liposomes as an ultrasonic contrast agent [J ]. J Pharm Sci, 1996,85 ( 5 ) :486-490.
  • 5梁海东 ,王兴华 ,Charles Sennoga ,Mike Halliwell ,David O Cosgrove ,Martin JK Blomley .超声微泡造影影像学及治疗作用的研究进展[J].中华医学超声杂志(电子版),2004,1(3):138-141. 被引量:4
  • 6BIomlevMJ,CookeJC,UngerEC,eta1.Microbubblecontrastagents:anewerainultrasound[J].BMJ,2001,322(7296):1222-1225.
  • 7KlibanovAL,GaschePT,HughesMS,eta1.Detectionofindividualmi.erobubblesofultrasoundcontrastagentsimagingoffree,floatingandtar.getedbubbles[J].InvestRadiol,2004,39(3):187-195.
  • 8区文超,刘伊丽.超声微泡介导靶向传输基因和药物的研究进展[J].心血管病学进展,2004,25(3):184-186. 被引量:18
  • 9Jeppesen C,Wong JY, Kuhl TL, et al. Impact of polymer tether length on multiple ligand-receptor bond formation [ J ]. Science, 2001,293 (5529) :465-468.
  • 10Klibanov AL. Ligand-carrying gas-filled microbubbles : uhrasound cont rastagents for targeted molecular imaging[ J ]. Bioconjugate Chem, 2005, 16(1) :9-17.

二级参考文献77

  • 1王兴华,于晓玲,董宝玮.超声介导超声造影剂在分子影像与基因治疗领域中的应用[J].中华超声影像学杂志,2004,13(11):865-867. 被引量:13
  • 2张群霞,王志刚,冉海涛,彭晓琼,李晓东,彭明利,刘宪华,景香香,杨春江.超声微泡促进肿瘤细胞报告基因转染[J].临床超声医学杂志,2005,7(2):78-80. 被引量:17
  • 3[2]Guzman HR, McNamara AJ, Nguyen DX, et al. Bioeffects caused by changes in acoustic cavitation bubble density and cell concentration: a unified explanation based on cell-to-bubble ratio and blast radius[J]. Ultrasound Med Biol, 2003, 29(8):1211-1222.
  • 4[3]Guzman HR, Nguyen DX, Khan S, et al. Ultrasound-mediated disruption of cell membranes. II. Heterogeneous effects on cells[J]. J Acoust Soc Am, 2001,110(1):597-606.
  • 5[4]Miller DL, Pislaru SV, Greenleaf JE. Sonoporation: mechanical DNA delivery by ultrasonic cavitation[J]. Somat Cell Mol Genet, 2002,27(1-6):115-134.
  • 6[5]Miller DL, Gies RA. The influence of ultrasound frequency and gas-body composition on the contrast agent-mediated enhancement of vascular bioeffects in mouse intestine[J]. Ultrasound Med Biol, 2000,26(2):307-313.
  • 7[6]Chen S, Kroll MH, Shohet RV, et al. Bioeffects of myocardial contrast microbubble destruction by echocardiography[J]. Echocardiography, 2002, 19(6):495-500.
  • 8[7]Miller DL, Gies RA. The influence of ultrasound frequency and gas-body composition on the contrast agent-mediated enhancement of vascular bioeffects in mouse intestine[J]. Ultrasound Med Biol, 2000,26(2):307-313.
  • 9[9]Miller DL, Gies RA. The influence of ultrasound frequency and gas-body composition on the contrast agent-mediated enhancement of vascular bioeffects in mouse intestine[J]. Ultrasound Med Biol, 2000,26(2):307-313.
  • 10[10]Miller DL, Song J. Lithotripter shock waves with cavitation nucleation agents produce tumor growth reduction and gene transfer in vivo[J]. Ultrasound Med Biol, 2002,28(10):1343-1348.

共引文献112

同被引文献24

  • 1王志刚.超声造影剂基础研究现状与进展[J].中华医学超声杂志(电子版),2011,8(5):924-928. 被引量:31
  • 2刘吉斌;王金锐.超声造影显像[M]北京:科学技术文献出版社,20106.
  • 3Weissleder R. Ultrasound U molecular imaging[J].Radiology,2001,(02):316-333.
  • 4Diaz-Lopez R,Tsapis N,Santin M. The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent[J].Biomaterials,2010,(05):1723-1731.doi:10.1016/j.biomaterials.2009.11.044.
  • 5Aaron FHL,Mark AB,Paul AD. Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles[J].Journal of Controlled Release,2006,(1/2):128-134.
  • 6Wilson SR,Burns PN. Microbubble-enhanced US in body imaging:what role[J].Radiology,2010,(01):24-39.
  • 7Danila M,Popescu A,Sirli R. Contrast enhanced ultrasound(CEUS) in the evaluation of liver metastases[J].Med Ultrason,2010,(03):233-237.
  • 8Deshpande N,Needles A,Willmann JK. Molecular ultrasound imaging:current status and future directions[J].Clinical Radiology,2010,(07):567-581.
  • 9Willmann JK,Lutz AM,Paulimurugran R. Dual targeted contrast agent for US assessment of tumor angiogenesis in vivo[J].Radiology,2008,(03):936-944.doi:10.1148/radiol.2483072231.
  • 10Dai J,Zou S,Pei Y. Polyethylenimine-grafted copolymer of poly(L-lysine) and poly(ethylene glycol) for gene delivery[J].Biomaterials,2011,(06):1694-1705.

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部