三阴性乳腺癌的临床病理特征分析

Clinicopathological features of triple-negative breast cancer

目的探讨三阴性乳腺癌(TNBC)的临床病理特征。方法回顾性分析4年间资料完整的3 8例TNBC患者临床资料,包括患者的一般状况、病理特点、分子标志物、复发与转移状况,并与同期非TNBC进行比较。结果≤35岁的患者在TNBC及非TNBC中分别占21.05%(8/38)和5.14%(15/292)(P<0.05)。TNBC组中有淋巴结转移者60.53%(23/38),高于非TNBC的43.49%(127/292)(P<0.05),TNBC组中组织学III级者52.63%(20/38)高于非TNBC组的35.27%(103/292)(P<0.05),TNBC中有瘤周脉管侵犯者占31.58%(12/38)高于非TNBC的15.41%(45/292)(P<0.05)。TNBC组表皮生长因子受体(EGFR)阳性率、血管内皮生长因子(VEGF)阳性率、E-钙黏附蛋白(E-cad)异常表达率分别为81.58%(31/38),78.95%(30/38),65.79%(25/38),高于非TNBC组的39.73%(116/292),61.30%(179/292),48.29%(141/292)(均P<0.05)。远处转移率在TNBC组中分别为2 3.6 8%(9/3 8),非TNBC为1 1.9 9%(3 5/2 9 2),差异有统计学意义(P<0.05)。结论 TNBC较多见于年轻患者,浸润转移率高,预后不良。

Objective To identify the elinieopathological features of triple-negative breast cancer （TNBC）. Methods There were 38 TNBC patients with complete records available who were admitted to our hospital over a 4- year period. Their clinical data that included the general conditions, pathological features, molecular markers, recurrence and metastasis were retrospectively analyzed and were compared with those of non-TNBC patients admitted during the same period. Results In the TNBC and non-TNBC patients, the cases less than 35 years old accounted for 21.05% and 5. 14% , respectively （P 〈 0.05 ）. The patients with lymph nodes metastases accounted for 60.53% （23/38） of the TNBC patients, which was higher than that of the uou-TNBC patients （43.49%, 127/292） （P 〈 0.05 ）. Tumors of histological grade III were found in 52. 63% （20/38） of the TNBC patients, which was higher than that of the non-TNBC patients （35.27% , 103/292） （P 〈0.05）. Peritumoral vascular invasion occurred in 31. 58% （12/38） of TNBC patients, which was higher than that of the non-TNBC patients （ 15.41% , 45/292 ） （ P 〈 0.05 ）. The positive rate of epidermal growth factor receptor （EGFR） and vascular endothelial growth factor （VEGF） , and the abnormal expression rate of E-cadherin were 81.58% （31/38） , 78.95% （30/38） and 65.79% （25/38）, respectively, in the TNBC patients, all which were higher than those in the non-TNBC patients ~39.73% （116/292） , 61. 30% （179/292） and 48. 29% （141/292） ] （all P〈0.05）. The distant metastasis rate was 23. 68% （9/38） in the TNBC patients and 11. 99% （ 35/292 ） in the uon-TNl^C patients, respectively, and that was statistically different （ P 〈 0. 05 ）. Conclusions TNBC usually occurs in young people, and has a higher metastasis rate and poor prognosis.