兔VX-2肺种植肿瘤CT灌注成像定量检测可重复性的研究

Quantitative Reproducibility Study of CT Perfusion Parameters in Rabbits with Implanted VX-2 Lung Tumors

目的前瞻性评估兔VX-2肺种植肿瘤CT灌注检查测量参数的可重复性。材料与方法10只肺种植肿瘤的新西兰大白兔行2次CT灌注检查(间隔24h),分别测量肿瘤体积、最大径、血容量、血流量、达峰时间、表面通透性(PS)、Patlak血容量(PBV)、PatlakR方程(PatRsq)及Patlak残差(PatRes)。使用Bland-Altman法分析2组CT测量数据的可重复性。结果 2次CT检查所有的CT灌注参数均显示较好的一致性,组内相关系数(ICC)均>0.6,个体间变异系数(WCV)10.8%～30.2%。其中,PS和PBV的WCV分别为10.8%和12.3%,与CT形态学指标体积及最大径相仿(8.5%和10.0%)。结论通过动物实验验证了肺种植肿瘤CT灌注的可重复性,初步确定了CT灌注参数变化的参考值范围,为进一步研究提供了实验数据。

Purpose To prospectively evaluate the reproducibility of CT perfusion parameters in rabbits with implanted VX2 lung tumors. Materials and Methods Perfusion CT was performed twice with 24-hour interval in 10 New Zealand White rabbits with implanted VX2 lung tumors. The volume, maximum diameter, blood volume （BV）, Blood flow （BF）, Time to peak （TTP）, Permeability surface （PS）, Patlak BV （PBV）, Patlak R square （PatRsq） and Patlak Residual （PatRes） were measured, and reproducibility was evaluated using Bland-Altman statistics. Results CT perfusion parameters showed good agreement between two perfusion examinations. Intragroup correlation coefficients （ICCs） were all more than 0.6, within-subject coefficient of variation （WCV） was from 10.8% to 30.2%. The WCV of PS （10.8%） and PBV （12.3%） showed excellent agreement between studies comparable to the WCV of volume （8.5%） and maximum diameter （10.0%）. Conclusion The trial confirms that lung tumor perfusion CT yields a good reproducibility and a range of reference values for CT perfusion parameters.