原发性高血压患者尿蛋白与肌酐比值和心血管危险因素的关系

Relationship between urinary albumin to creatinine ratio and cardiovascular risk factors in primary hypertension patients

目的探讨在原发性高血压人群中微量白蛋白尿(MAU)的发生与心血管危险因素的相关性。方法从社区体检中心筛查出原发性高血压患者530例,收集研究对象的一般资料,并进行血生化指标及尿蛋白与肌酐比值的测定,根据检查结果分为MAU阳性组(n=141)及MAU阴性组(n=389)。结果 MAU阳性组年龄较大,男性及吸烟比例居多,收缩压、腰围、体质量指数、空腹血糖、糖化血红蛋白、尿酸、脉压差及平均动脉压明显高于MAU阴性组(均P<0.05);多元线性回归显示收缩压、糖化血红蛋白、总胆固醇及体质量指数是MAU发生的独立危险因素(P<0.05)。结论收缩压、糖化血红蛋白、总胆固醇及体质量指数是原发性高血压人群中MAU发生的独立危险因素。

Objective To explore the relationship between microalbuminuria and cardiovascular risk factors in pa- tients with hypertension. Methods Five hundred thirty hypertensive patients were recruited from community med- ical center. Cardiovascular risk factors and urinary albumin to creatinine ratio were assesed in all participants. Of the study population,26.6% （n=141） had microalbuminuria. Results Compared to those with non-microalbumin- uria, those with microalbuminuria were older, more likely to be of male sex and smoking. In comparison with non-microalbuminuria group, systolic blood pressure, waist circumference, body mass index, fasting blood glucose, gly-cated hemoglobin, uric acid, pulse pressure differential and mean arterial pressure were significantly higher （P〈0.05}. Multiple linear regression analysis indicated that the factors that were associated independently with microalbuminuria were systolic blood pressure, glycated hemoglobin, total cholesterol, and body mass index （P〈0.05）, while smoking, age, diastolic pressure, triglycerides, and high-density lipoprotein had no relationship with microalbuminuria {P〉0.05）. Conclusion In patients with hypertension,systolic blood pressure, glycated hemo-globin, total cholesterol, and body mass index are associated independently with microalbuminuria.