黄体中期子宫内膜轻创对冷冻胚胎移植妊娠结局的影响

Influence of Local Injury to the Endometrium during Midluteal Phase on Frozen Embryo Transfer Pregnancy Outcome

目的:探讨黄体中期子宫内膜轻创对下一个周期冷冻胚胎移植妊娠结局的影响。方法:回顾性分析进行冷冻胚胎移植的143例患者的临床资料,其中29个周期黄体中期行子宫内膜轻创(轻创组),114个FET周期未行此项干预(对照组),比较两组的妊娠结局。结果:轻创组临床妊娠率为62.07%,对照组临床妊娠率为44.35%,前者有明显的增高趋势,但无统计学差异。对照组中自然周期准备内膜(n=70)和人工周期准备内膜(n=44)的临床妊娠率分别是48.57%和38.64%,两者相比无统计学差异。结论:对于反复种植失败的患者于FET的前一个周期的黄体中期轻创子宫内膜可以在一定程度上提高临床妊娠率。FET时自然周期和人工周期准备内膜其临床妊娠率无明显差异。

Objective： To explore the influence of local injury to the endometrium during midluteal phase on the subsequent frozen embryo transfer（FET） cycle pregnancy outcome.Methods：A total of 143 FET cycles were retrospectively analyzed 29 patients from local injury group were taken to undergo local injury to the endometriunm during midluteal phase and proceed with FET,while 114 cycles were taken proceed with FET as the control.Hematoxylin and eosin stain were used to assessment endometrial dating.The control were divided into natural cycles and hormonally controlled cycles.Results： The clinical pregnancy rate in the local injury group was 62.07%,which was much higher than that in the control（44.35%）,but there were no significant differences between the two groups（P=0.095）.There were 48.57% clinical pregnancy rate in natural cycles group compared with 38.64% in hormonally controlled cycles group（P0.05）.Conclusion： That patients who had repeated implantation failure were offered to undergo endometrial local injury during midluteal phase prior to the FET cycle.That management may increase the clinical pregnancy rate of the subsequent FET cycle.There were no significant differences between the natural cycles and the hormonally controlled cycles in FET cycle.