摘要
目的 探讨Syndecan-1,bFGF在子宫内膜癌中的表达及意义.方法 采用免疫组织化学法检测50例子宫内膜癌、26例不典型增生及20例正常子宫内膜组织中Syndecan-1,bFGF的蛋白表达.结果 Syndecan-1,bFGF在子宫内膜癌、不典型增生及正常子宫内膜组织中的强阳性表达率分别为56.00%,88.00%,88.89%和66.00%,32.00%,27.80%,且均有统计学意义（P〈0.05）.Syndecan-1的低表达与组织学分级、有无肌层浸润、临床分期和有无淋巴结转移有关.bFGF的高表达与组织学分级、有无肌层浸润和临床分期有关,与有无淋巴结转移无关.结论 Syndecan-1蛋白低表达及bFGF蛋白高表达在子宫内膜癌的转移中起重要作用,并影响其预后.
Objective To analyze the expression and clinical significance of Syndecan-1and bFGF in endometrial cancer tissue. Methods Syndecan-I and bFGF proteins were detected immunohistoehemically in 50 patients with endometrial adenocarcinoma,25 with normal endometria and 18 with atypia hyperplasia. Results The positive expression rate of Syndecan-1 and bFGF in normal endometria,atypia hyperplasia,and endometrial cancer were 88.89% ,88.00% , 56.00% and 27.78% ,32.00% ,66.00% ,respectively. There were significant differences among the three groups（P 〈 0.05）. Low expression level of Syndecan-1 was associated with tumor differentiation,depth of invasion, the clinical stage and the focal lymph node metastasis（ P 〈 0.05 ）. High expression level of hFGF was associated with tumor differentiation, depth of invasion, the clinical stage （ P 〈 0.05 ）, but not with the focal lymph node metastasis （ P 〉 0.05 ） . Conclusion The expression of Syndecan-1 and hFGF in endometrial cancer tissue was closely correlated with the invasion.
出处
《潍坊医学院学报》
2011年第1期33-35,共3页
Acta Academiae Medicinae Weifang
