寻常性银屑病患者血清IL-17和IL-22检测与其PASI评分的相关性分析

Expression of IL-17,IL-22 in the Serum of Patients with Psoriasis Vulgaris and It's Correlationship with PASI Score

目的探讨寻常性银屑病患者血清IL-17和IL-22的水平与皮损面积和严重程度指数(PASI评分)的相关性。方法采用ELISA法检测29例寻常性银屑病患者血清中IL-17和IL-22的水平,并以11例健康人作为对照。结果银屑病患者血清IL-17的水平21.255(37.181)pg/mL高于正常对照组的7.464(29.880)pg/mL,IL-22的水平56.970(42.720)pg/mL高于正常对照组的40.943(62.120)pg/mL,进展期组银屑病患者血清IL-17水平30.884(41.433)pg/mL高于静止期组患者的14.225(22.831)pg/mL,差异均有统计学意义(P均<0.05);静止期组银屑病患者血清IL-22水平56.974(64.394)pg/mL高于进展期组患者的52.876(43.015)pg/mL,但差异无统计学意义(P>0.05)。血清IL-17和IL-22水平与PASI评分结果无直线相关关系(P>0.05)。结论寻常性银屑病患者血清IL-17和IL-22水平上调,可能参与银屑病的发病,但其与PASI评分无相关关系。

Objective To investigate the expression of IL-17 and IL-22 in the serum of patients with psoriasis vulgaris and its eorrelationship with psoriasis area and severity index （PASI）. Methods The expression of IL-17 and IL-22 was measured by enzyme-linked immunosorbent assay （ELISA） in 29 patients with psoriasis vulgaffs and 11 normal controls. Results The expression of IL-17 [ 21. 255 （37. 181 ）pg/mL] in serum was higher than that in the normal control [ 7. 464 （ 29. 880） pg/mL ], The expression of IL-22 [ 56.970 （ 42. 720 ） pg/mL] in serum was higher than that in the normal control [40. 943 （62. 120）pg/mL], the expression of IL-17 in the progression stage group[ 30.884 （41. 433 ）pg/mL] was higher than that in the stationary stage group [ 14. 225 （22.831 ）pg/mL ], the difference was statistically significant （all P 〈 0. 05 ） ; The expression of IL-22 in the progression stage group [ 56. 974 （64. 394）pg/mL ] was higher than that in the stationary stage group [ 52. 876 （43. 015 ） pg/mL 1, the difference was not statistically significant （ P 〉 0. 05 ） ; The expression of IL-17 and IL-22 and the clinical severity degree （PASI） had no linear correlation （P 〉 0.05）. Conclusion The expression of IL-17 and IL-22 in the serum of patients with psoriasis vulgaris is up-regulated, so IL-17 and IL-22 may participate in the development of disease, but its and PASI score was not relevance.